ADAM10

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAM10 yw ADAM10 a elwir hefyd yn Disintegrin and metalloproteinase domain-containing protein 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q21.3.

ADAM10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M1I
Dynodwyr
Cyfenwau	ADAM10, AD10, AD18, CD156c, HsT18717, MADM, RAK, kuz, CDw156, ADAM metallopeptidase domain 10
Dynodwyr allanol	OMIM: 602192 HomoloGene: 865 GeneCards: ADAM10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • SH3 domain binding • endopeptidase activity • metal ion binding • integrin binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • signaling receptor binding • hydrolase activity • protein kinase binding • metallopeptidase activity • metalloendopeptidase activity Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • GO:0097483, GO:0097481 postsynaptic density • focal adhesion • Cellbilen • perinuclear endoplasmic reticulum • Golgi-associated vesicle • tetraspanin-enriched microdomain • extracellular exosome • cnewyllyn cell • cell surface • Golgi membrane • extracellular space • Golgi apparatus • specific granule membrane • tertiary granule membrane • endoplasmic reticulum lumen • trans-Golgi network • synaptic vesicle • dendrite • soma • dendritic spine • postsynaptic membrane • postsynapse • glutamatergic synapse Prosesau biolegol • Notch signaling pathway • positive regulation of cell migration • ephrin receptor signaling pathway • cell-cell signaling • constitutive protein ectodomain proteolysis • protein processing • extracellular matrix disassembly • in utero embryonic development • proteolysis • monocyte activation • response to tumor necrosis factor • protein phosphorylation • positive regulation of cell growth • positive regulation of T cell chemotaxis • positive regulation of cell population proliferation • Notch receptor processing • integrin-mediated signaling pathway • membrane protein ectodomain proteolysis • negative regulation of cell adhesion • neutrophil degranulation • post-translational protein modification • spermatogenesis • amyloid-beta formation • Notch receptor processing, ligand-dependent • positive regulation of apoptotic process • regulation of dendritic spine morphogenesis • response to antineoplastic agent • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane • postsynapse organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	102	n/a
Ensembl	ENSG00000137845	n/a
UniProt	O14672	n/a
RefSeq (mRNA)	NM_001110 NM_001320570	n/a
RefSeq (protein)	NP_001101 NP_001307499 NP_001101.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADAM10.

• RAK
• kuz
• AD10
• AD18
• MADM
• CD156c
• CDw156
• HsT18717

Llyfryddiaeth

• "Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. ". Cell. 2017. PMID 29224781.
• "Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins. ". Biochem Soc Trans. 2017. PMID 28687716.
• "Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins. ". Biochem Soc Trans. 2017. PMID 28620033.
• "ADAM 10 expression in primary uveal melanoma as prognostic factor for risk of metastasis. ". Pathol Res Pract. 2016. PMID 27546281.
• "ADAM10 localization in temporomandibular joint disk with internal derangement: an ex vivo immunohistochemical study.". Acta Histochem. 2016. PMID 26947053.