ADAM17

ADAM17
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BKC, 1ZXC, 2A8H, 2DDF, 2FV5, 2FV9, 2I47, 2M2F, 2OI0, 3B92, 3CKI, 3E8R, 3EDZ, 3EWJ, 3G42, 3KMC, 3KME, 3L0T, 3L0V, 3LE9, 3LEA, 3LGP, 3O64
Dynodwyr
Cyfenwau	ADAM17, ADAM18, CD156B, CSVP, NISBD, NISBD1, TACE, ADAM metallopeptidase domain 17
Dynodwyr allanol	OMIM: 603639 HomoloGene: 2395 GeneCards: ADAM17
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• PDZ domain binding; • interleukin-6 receptor binding; • SH3 domain binding; • metal ion binding; • Notch binding; • integrin binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • metalloendopeptidase activity; • hydrolase activity; • metallopeptidase activity; • endopeptidase activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • cell-cell junction; • focal adhesion; • Cellbilen; • integral component of plasma membrane; • ruffle membrane; • cell surface; • apical plasma membrane; • actin cytoskeleton; • membrane raft; • cytosol;
Prosesau biolegol	• Notch signaling pathway; • positive regulation of transforming growth factor beta receptor signaling pathway; • positive regulation of epidermal growth factor-activated receptor activity; • positive regulation of protein phosphorylation; • response to hypoxia; • T cell differentiation in thymus; • cell motility; • positive regulation of cell migration; • wound healing, spreading of epidermal cells; • germinal center formation; • tumor necrosis factor-mediated signaling pathway; • negative regulation of transforming growth factor beta receptor signaling pathway; • spleen development; • proteolysis; • positive regulation of leukocyte chemotaxis; • positive regulation of cell growth; • response to lipopolysaccharide; • cell adhesion; • cell adhesion mediated by integrin; • membrane protein ectodomain proteolysis; • membrane protein intracellular domain proteolysis; • regulation of mast cell apoptotic process; • positive regulation of T cell chemotaxis; • positive regulation of cell population proliferation; • Notch receptor processing; • positive regulation of chemokine production; • neutrophil mediated immunity; • B cell differentiation; • GO:0051637 defense response to Gram-positive bacterium; • epidermal growth factor receptor signaling pathway; • receptor transactivation; • positive regulation of blood vessel endothelial cell migration; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • cellular response to high density lipoprotein particle stimulus; • negative regulation of cold-induced thermogenesis; • positive regulation of G1/S transition of mitotic cell cycle; • positive regulation of tumor necrosis factor-mediated signaling pathway; • positive regulation of vascular endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	6868
	n/a
	ENSG00000151694
	n/a
	P78536
	n/a
	NM_003183; NM_001382777; NM_001382778; NM_021832
	n/a
	NP_003174
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ADAM17 yw ADAM17 a elwir hefyd yn ADAM17 protein ac ADAM metallopeptidase domain 17 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p25.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ADAM17.

CSVP
TACE
NISBD
ADAM18
CD156B
NISBD1

Llyfryddiaeth

"Hypoxia-induced ADAM 17 expression is mediated by RSK1-dependent C/EBPβ activation in human lung fibroblasts. ". Mol Immunol. 2017. PMID 28646679.
"ADAM17 promotes epithelial-mesenchymal transition via TGF-β/Smad pathway in gastric carcinoma cells. ". Int J Oncol. 2016. PMID 27779657.
"Association Study Between Promoter Polymorphisms of ADAM17 and Progression of Sepsis. ". Cell Physiol Biochem. 2016. PMID 27607600.
"Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes. ". Biochim Biophys Acta. 2016. PMID 27599715.
"Expression of Migration-Related Genes in Human Colorectal Cancer and Activity of a Disintegrin and Metalloproteinase 17.". Biomed Res Int. 2016. PMID 27110571.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ADAM17 - Cronfa NCBI

[2]

[1]