APOE

APOE
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B
Dynodwyr
Cyfenwau	APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4
Dynodwyr allanol	OMIM: 107741 HomoloGene: 30951 GeneCards: APOE
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• heparin binding; • very-low-density lipoprotein particle receptor binding; • low-density lipoprotein particle receptor binding; • lipoprotein particle binding; • phosphatidylcholine-sterol O-acyltransferase activator activity; • phospholipid binding; • GO:0017127 cholesterol transfer activity; • protein homodimerization activity; • amyloid-beta binding; • GO:0001948, GO:0016582 protein binding; • tau protein binding; • metal chelating activity; • lipid transporter activity; • cholesterol binding; • antioxidant activity; • identical protein binding; • lipid binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • chylomicron; • extracellular region; • cnewyllyn cell; • extracellular vesicle; • endocytic vesicle lumen; • very-low-density lipoprotein particle; • hylif allgellog; • Reticwlwm endoplasmig; • extracellular exosome; • Golgi apparatus; • blood microparticle; • GO:0005578 extracellular matrix; • Cellbilen; • neuronal cell body; • early endosome; • low-density lipoprotein particle; • dendrite; • high-density lipoprotein particle; • intermediate-density lipoprotein particle;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • response to dietary excess; • negative regulation of lipid transport across blood-brain barrier; • lipid transport; • positive regulation of lipid biosynthetic process; • regulation of axon extension; • positive regulation of postsynaptic membrane organization; • positive regulation of cholesterol esterification; • phospholipid efflux; • cholesterol catabolic process; • positive regulation of dendritic spine development; • receptor-mediated endocytosis; • retinoid metabolic process; • positive regulation of amyloid-beta formation; • lipid homeostasis; • lipoprotein biosynthetic process; • cholesterol homeostasis; • negative regulation of inflammatory response; • triglyceride metabolic process; • negative regulation of canonical Wnt signaling pathway; • negative regulation of dendritic spine maintenance; • negative regulation of blood vessel endothelial cell migration; • NMDA glutamate receptor clustering; • GO:0001315 response to reactive oxygen species; • negative regulation of blood coagulation; • GO:0001306 response to oxidative stress; • positive regulation of nitric-oxide synthase activity; • negative regulation of phospholipid efflux; • positive regulation of cholesterol efflux; • negative regulation of MAP kinase activity; • artery morphogenesis; • very-low-density lipoprotein particle remodeling; • regulation of neuronal synaptic plasticity; • negative regulation of dendritic spine development; • negative regulation of cholesterol biosynthetic process; • positive regulation of dendritic spine maintenance; • positive regulation of phospholipid efflux; • negative regulation of presynaptic membrane organization; • negative regulation of neuron death; • high-density lipoprotein particle clearance; • long-chain fatty acid transport; • lipoprotein metabolic process; • regulation of tau-protein kinase activity; • G protein-coupled receptor signaling pathway; • chylomicron remnant clearance; • cellular calcium ion homeostasis; • cholesterol metabolic process; • very-low-density lipoprotein particle clearance; • virion assembly; • negative regulation of lipid biosynthetic process; • cGMP-mediated signaling; • triglyceride catabolic process; • positive regulation of presynaptic membrane organization; • positive regulation of neurofibrillary tangle assembly; • AMPA glutamate receptor clustering; • positive regulation of low-density lipoprotein particle receptor catabolic process; • positive regulation of lipid transport across blood-brain barrier; • fatty acid homeostasis; • nitric oxide mediated signal transduction; • GO:0015915 transport; • cholesterol efflux; • regulation of gene expression; • negative regulation of cholesterol efflux; • regulation of amyloid-beta clearance; • neuron projection regeneration; • negative regulation of postsynaptic membrane organization; • steroid metabolic process; • regulation of Cdc42 protein signal transduction; • lipid metabolism; • negative regulation of amyloid-beta formation; • positive regulation of membrane protein ectodomain proteolysis; • vasodilation; • intracellular transport; • synaptic transmission, cholinergic; • positive regulation of neuron death; • high-density lipoprotein particle assembly; • protein import; • high-density lipoprotein particle remodeling; • negative regulation of endothelial cell proliferation; • maintenance of location in cell; • negative regulation of platelet activation; • low-density lipoprotein particle remodeling; • positive regulation by host of viral process; • cytoskeleton organization; • regulation of neuron death; • reverse cholesterol transport; • lipoprotein catabolic process; • triglyceride homeostasis; • cellular oxidant detoxification; • lipid transport involved in lipid storage;
	Sources:Amigo / QuickGO
Orthologau
	348
	n/a
	ENSG00000130203
	n/a
	P02649
	n/a
	NM_001302691; NM_000041; NM_001302688; NM_001302689; NM_001302690
	n/a
	NP_000032; NP_001289617; NP_001289618; NP_001289619; NP_001289620
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn APOE yw APOE a elwir hefyd yn Apolipoprotein E (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.32.^[2]

Cyfystyron golygu

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APOE.

AD2
LPG
APO-E
ApoE4
LDLCQ5

Llyfryddiaeth golygu

"APOE allele frequencies in suspected non-amyloid pathophysiology (SNAP) and the prodromal stages of Alzheimer's Disease. ". PLoS One. 2017. PMID 29190651.
"IS APOLIPOPROTEIN E Îµ2 ASSOCIATED WITH DELAYED ONSET OF NON-LESIONAL TEMPORAL LOBE EPILEPSY?". Acta Clin Croat. 2017. PMID 29120117.
"Apolipoprotein A-I attenuates LL-37-induced endothelial cell cytotoxicity. ". Biochem Biophys Res Commun. 2017. PMID 28919413.
"Modelling APOE É›3/4 allele-associated sporadic Alzheimer's disease in an induced neuron. ". Brain. 2017. PMID 28899010.
"Indispensable role of lipoprotein bound-ApoE in adipogenesis and endocytosis induced by postprandial TRL.". Biochem Biophys Res Commun. 2017. PMID 28893538.

Cyfeiriadau golygu

[1] "Human PubMed Reference:".

[2] APOE - Cronfa NCBI

[2]

[1]