IL6

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL6 yw IL6 a elwir hefyd yn Interleukin-6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7p15.3.

IL6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4O9H, 1ALU, 1IL6, 1P9M, 2IL6, 4CNI, 4J4L, 4NI7, 4NI9, 4ZS7
Dynodwyr
Cyfenwau	IL6, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6
Dynodwyr allanol	OMIM: 147620 HomoloGene: 502 GeneCards: IL6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • growth factor activity • interleukin-6 receptor binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular region • interleukin-6 receptor complex • extracellular space • endoplasmic reticulum lumen Prosesau biolegol • regulation of angiogenesis • positive regulation of translation • platelet activation • humoral immune response • defense response to virus • response to peptidoglycan • neuron projection development • GO:0051637 defense response to Gram-positive bacterium • negative regulation of fat cell differentiation • positive regulation of peptidyl-serine phosphorylation • positive regulation of leukocyte chemotaxis • positive regulation of T cell proliferation • positive regulation of interleukin-6 production • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of acute inflammatory response • inflammatory response • negative regulation of collagen biosynthetic process • positive regulation of MAPK cascade • hepatic immune response • monocyte chemotaxis • positive regulation of DNA-binding transcription factor activity • negative regulation of apoptotic process • positive regulation of osteoblast differentiation • positive regulation of NF-kappaB transcription factor activity • acute-phase response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of vascular endothelial growth factor production • positive regulation of chemokine production • negative regulation of lipid storage • neutrophil mediated immunity • positive regulation of smooth muscle cell proliferation • positive regulation of type B pancreatic cell apoptotic process • response to glucocorticoid • GO:0051636 defense response to Gram-negative bacterium • positive regulation of cell population proliferation • positive regulation of apoptotic process • positive regulation of B cell activation • post-translational protein modification • regulation of signaling receptor activity • positive regulation of tyrosine phosphorylation of STAT protein • neutrophil apoptotic process • negative regulation of cell population proliferation • GO:1901313 positive regulation of gene expression • endocrine pancreas development • negative regulation of bone resorption • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • glucagon secretion • cellular response to hydrogen peroxide • cellular response to lipopolysaccharide • T-helper 17 cell lineage commitment • positive regulation of T-helper 2 cell cytokine production • negative regulation of interleukin-1-mediated signaling pathway • cytokine-mediated signaling pathway • interleukin-6-mediated signaling pathway • positive regulation of receptor signaling pathway via JAK-STAT • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3569	n/a
Ensembl	ENSG00000136244	n/a
UniProt	P05231	n/a
RefSeq (mRNA)	NM_000600 NM_001318095 NM_001371096	n/a
RefSeq (protein)	NP_000591 NP_001305024 NP_001358025	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL6.

• CDF
• HGF
• HSF
• BSF2
• IL-6
• BSF-2
• IFNB2
• IFN-beta-2

Llyfryddiaeth

• "The Role of Interleukin-6 in Castleman Disease. ". Hematol Oncol Clin North Am. 2018. PMID 29157617.
• "Elevated Serum Interleukin-6 Predicts Favorable Response to Immunosuppressive Therapy in Children With Aplastic Anemia. ". J Pediatr Hematol Oncol. 2017. PMID 29068868.
• "Measurement of Interleukin-6 in Cerebrospinal Fluid for the Diagnosis of Bacterial Meningitis. ". Pak J Biol Sci. 2016. PMID 29022995.
• "Polymorphisms of interleukin 6 in Down syndrome individuals: a case-control study. ". Genet Mol Res. 2017. PMID 28829905.
• "IL-6 variant is associated with metastasis in breast cancer patients.". PLoS One. 2017. PMID 28732081.