ITGB2

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGB2 yw ITGB2 a elwir hefyd yn Integrin beta ac Integrin subunit beta 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q22.3.

ITGB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1L3Y, 1YUK, 2JF1, 2P26, 2P28, 3K6S, 3K71, 3K72, 2V7D, 4NEH, 4NEN, 5E6X, 5E6V, 5E6S, 5E6R, 5E6W, 5ES4, 5E6U
Dynodwyr
Cyfenwau	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
Dynodwyr allanol	OMIM: 600065 HomoloGene: 20092 GeneCards: ITGB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0032403 protein-containing complex binding • metal ion binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • ICAM-3 receptor activity • protein kinase binding • cell adhesion molecule binding • heat shock protein binding • amyloid-beta binding • complement component C3b binding • integrin binding • signaling receptor activity • cargo receptor activity Cydrannau o'r gell • integral component of membrane • extracellular vesicle • integrin alphaL-beta2 complex • bilen • Cellbilen • receptor complex • cell surface • integrin complex • extracellular exosome • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane • focal adhesion • external side of plasma membrane • integrin alphaM-beta2 complex • plasma membrane raft • membrane raft • cytoplasmic region • GO:0009327 protein-containing complex Prosesau biolegol • leukocyte cell-cell adhesion • endodermal cell differentiation • toll-like receptor 4 signaling pathway • positive regulation of nitric oxide biosynthetic process • heterotypic cell-cell adhesion • cell-cell signaling • GO:0010260 heneiddio • receptor internalization • leukocyte migration involved in inflammatory response • natural killer cell activation • cellular response to low-density lipoprotein particle stimulus • extracellular matrix organization • receptor clustering • positive regulation of angiogenesis • neutrophil chemotaxis • cell adhesion • positive regulation of NF-kappaB transcription factor activity • regulation of cell shape • regulation of immune response • cellular extravasation • integrin-mediated signaling pathway • cell-matrix adhesion • inflammatory response • endothelial cell migration • leukocyte migration • regulation of peptidyl-tyrosine phosphorylation • GO:0097285 apoptotic process • ffagocytosis • neutrophil degranulation • microglial cell activation • receptor-mediated endocytosis • phagocytosis, engulfment • cell migration • cytokine-mediated signaling pathway • positive regulation of superoxide anion generation • cell adhesion mediated by integrin • positive regulation of neutrophil degranulation • negative regulation of dopamine metabolic process • positive regulation of protein targeting to membrane • amyloid-beta clearance • cell-cell adhesion • cell-cell adhesion via plasma-membrane adhesion molecules • positive regulation of neuron death • positive regulation of microglial cell activation • neutrophil migration • positive regulation of prostaglandin-E synthase activity • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3689	n/a
Ensembl	ENSG00000160255	n/a
UniProt	P05107	n/a
RefSeq (mRNA)	NM_000211 NM_001127491 NM_001303238	n/a
RefSeq (protein)	NP_000202 NP_001120963 NP_001290167	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGB2.

• LAD
• CD18
• MF17
• MFI7
• LCAMB
• LFA-1
• MAC-1

Llyfryddiaeth

• "Altered levels of soluble CD18 may associate immune mechanisms with outcome in sepsis. ". Clin Exp Immunol. 2017. PMID 28714582.
• "LFA-1 Activation in NK Cells and Their Subsets: Influence of Receptors, Maturation, and Cytokine Stimulation. ". J Immunol. 2017. PMID 28100681.
• "Quantitative Protein Sulfenic Acid Analysis Identifies Platelet Releasate-Induced Activation of Integrin β2 on Monocytes via NADPH Oxidase. ". J Proteome Res. 2016. PMID 27690452.
• "CD18 promoter methylation is associated with a higher risk of thrombotic complications in primary myelofibrosis. ". Ann Hematol. 2016. PMID 27595148.
• "LFA-1 integrin antibodies inhibit leukocyte α4β1-mediated adhesion by intracellular signaling.". Blood. 2016. PMID 27443292.