EME1

Protein sy'n cael ei godio yn y corff dynol gan y genyn EME1 yw EME1 a elwir hefyd yn Essential meiotic structure-specific endonuclease 1 a Crossover junction endonuclease EME1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.33.

EME1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ZIU, 2ZIV, 2ZIW, 2ZIX, 4P0P, 4P0Q, 4P0R, 4P0S
Dynodwyr
Cyfenwau	EME1, MMS4L, SLX2A, essential meiotic structure-specific endonuclease 1
Dynodwyr allanol	OMIM: 610885 HomoloGene: 16123 GeneCards: EME1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • endonuclease activity • nuclease activity • GO:0001948, GO:0016582 protein binding • hydrolase activity • metal ion binding • endodeoxyribonuclease activity • crossover junction endodeoxyribonuclease activity Cydrannau o'r gell • nucleolus • nucleoplasm • cnewyllyn cell • Holliday junction resolvase complex Prosesau biolegol • cellular response to DNA damage stimulus • DNA recombination • interstrand cross-link repair • nucleic acid phosphodiester bond hydrolysis • response to intra-S DNA damage checkpoint signaling • GO:0100026 DNA repair • resolution of meiotic recombination intermediates • double-strand break repair • replication fork processing • mitotic intra-S DNA damage checkpoint signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	146956	n/a
Ensembl	ENSG00000154920	n/a
UniProt	Q96AY2	n/a
RefSeq (mRNA)	NM_001166131 NM_152463	n/a
RefSeq (protein)	NP_001159603 NP_689676	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EME1.

• MMS4L
• SLX2A

Llyfryddiaeth

• "Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. ". Proc Natl Acad Sci U S A. 2008. PMID 18310322.
• "Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. ". Nucleic Acids Res. 2006. PMID 16456034.
• "Functional evidence for Eme1 as a marker of cisplatin resistance. ". Int J Cancer. 2009. PMID 19267403.
• "Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates. ". EMBO J. 2014. PMID 24733841.
• "Crystal structure of the Mus81-Eme1 complex.". Genes Dev. 2008. PMID 18413719.