ENPP2

Protein sy'n cael ei godio yn y corff dynol gan y genyn ENPP2 yw ENPP2 a elwir hefyd yn Ectonucleotide pyrophosphatase/phosphodiesterase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q24.12.

ENPP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4ZGA, 4ZG6, 4ZG9, 4ZG7
Dynodwyr
Cyfenwau	ENPP2, ATX, ATX-X, AUTOTAXIN, LysoPLD, NPP2, PD-IALPHA, PDNP2, ectonucleotide pyrophosphatase/phosphodiesterase 2
Dynodwyr allanol	OMIM: 601060 HomoloGene: 4526 GeneCards: ENPP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide diphosphatase activity • phosphodiesterase I activity • transcription factor binding • polysaccharide binding • metal ion binding • scavenger receptor activity • catalytic activity • alkylglycerophosphoethanolamine phosphodiesterase activity • nucleic acid binding • hydrolase activity • calcium ion binding • lysophospholipase activity • zinc ion binding Cydrannau o'r gell • Cellbilen • integral component of plasma membrane • extracellular region • extracellular space • cytoplasm • Golgi apparatus Prosesau biolegol • G protein-coupled receptor signaling pathway • regulation of cell migration • positive regulation of lamellipodium morphogenesis • lipid metabolism • positive regulation of epithelial cell migration • regulation of angiogenesis • receptor-mediated endocytosis • lipid catabolic process • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • phospholipid catabolic process • positive regulation of peptidyl-tyrosine phosphorylation • phosphate-containing compound metabolic process • metabolaeth • chemotaxis • phosphatidylcholine catabolic process • nucleic acid phosphodiester bond hydrolysis • cell motility • phospholipid metabolic process • negative regulation of cell-matrix adhesion • positive regulation of cell population proliferation • diencephalon development • forebrain development • midbrain development • positive regulation of oligodendrocyte differentiation • positive regulation of focal adhesion assembly • cell chemotaxis • cellular response to cadmium ion • cellular response to estradiol stimulus • positive regulation of substrate adhesion-dependent cell spreading • response to polycyclic arene • vesicle-mediated transport • endocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5168	n/a
Ensembl	ENSG00000136960	n/a
UniProt	Q13822	n/a
RefSeq (mRNA)	NM_001040092 NM_001130863 NM_006209 NM_001330600	n/a
RefSeq (protein)	NP_001035181 NP_001124335 NP_001317529 NP_006200	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ENPP2.

• ATX
• NPP2
• ATX-X
• PDNP2
• LysoPLD
• AUTOTAXIN
• PD-IALPHA

Llyfryddiaeth

• "The critical role and potential target of the autotaxin/lysophosphatidate axis in pancreatic cancer. ". Tumour Biol. 2017. PMID 28347252.
• "Association between Promoter Hypomethylation and Overexpression of Autotaxin with Outcome Parameters in Biliary Atresia. ". PLoS One. 2017. PMID 28052132.
• "Overexpression of autotaxin is associated with human renal cell carcinoma and bladder carcinoma and their progression. ". Med Oncol. 2016. PMID 27757783.
• "During Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy. ". J Infect Dis. 2016. PMID 27540113.
• "Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.". J Struct Biol. 2016. PMID 27268273.