EP300

Protein sy'n cael ei godio yn y corff dynol gan y genyn EP300 yw EP300 a elwir hefyd yn E1A binding protein p300 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q13.2.

EP300
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3
Dynodwyr
Cyfenwau	EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2
Dynodwyr allanol	OMIM: 602700 HomoloGene: 1094 GeneCards: EP300
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein C-terminus binding • transcription factor binding • GO:0001104 transcription coregulator activity • metal ion binding • acyltransferase activity • transferase activity • beta-catenin binding • pre-mRNA intronic binding • zinc ion binding • chromatin binding • damaged DNA binding • GO:0001948, GO:0016582 protein binding • acetyltransferase activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • p53 binding • androgen receptor binding • chromatin DNA binding • histone acetyltransferase activity • lysine N-acetyltransferase activity, acting on acetyl phosphate as donor • peptide N-acetyltransferase activity • peptide-lysine-N-acetyltransferase activity • protein propionyltransferase activity • STAT family protein binding • peptide butyryltransferase activity • histone crotonyltransferase activity • histone butyryltransferase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell • histone acetyltransferase complex • transcription regulator complex • nucleoplasm • cytoplasm • cytosol • Cromosom Prosesau biolegol • somitogenesis • proses rythmig • transcription by RNA polymerase II • histone H2B acetylation • animal organ morphogenesis • cell cycle • B cell differentiation • GO:0097285 apoptotic process • GO:0009373 regulation of transcription, DNA-templated • lung development • N-terminal peptidyl-lysine acetylation • platelet formation • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • heart development • regulation of transcription from RNA polymerase II promoter in response to hypoxia • GO:0022415 viral process • protein acetylation • Notch signaling pathway • cellular response to UV • protein stabilization • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • nervous system development • regulation of autophagy • regulation of androgen receptor signaling pathway • positive regulation of protein binding • positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response • fat cell differentiation • positive regulation by host of viral transcription • megakaryocyte development • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • internal protein amino acid acetylation • regulation of cell cycle • regulation of tubulin deacetylation • GO:1901313 positive regulation of gene expression • histone H4 acetylation • regulation of cellular response to heat • transcription-coupled nucleotide-excision repair • skeletal muscle tissue development • positive regulation of type I interferon production • response to estrogen • response to hypoxia • regulation of signal transduction by p53 class mediator • internal peptidyl-lysine acetylation • beta-catenin-TCF complex assembly • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • macrophage derived foam cell differentiation • Rhythm circadaidd • protein deubiquitination • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein destabilization • regulation of megakaryocyte differentiation • histone acetylation • epigenetic maintenance of chromatin in transcription-competent conformation • peptidyl-lysine propionylation • peptidyl-lysine crotonylation • peptidyl-lysine butyrylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2033	n/a
Ensembl	ENSG00000100393	n/a
UniProt	Q09472	n/a
RefSeq (mRNA)	NM_001429 NM_001362843	n/a
RefSeq (protein)	NP_001420 NP_001349772	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EP300.

• p300
• KAT3B
• RSTS2

Llyfryddiaeth

• "A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease. ". Neurotox Res. 2016. PMID 27256286.
• "From Whole Gene Deletion to Point Mutations of EP300-Positive Rubinstein-Taybi Patients: New Insights into the Mutational Spectrum and Peculiar Clinical Hallmarks. ". Hum Mutat. 2016. PMID 26486927.
• "Molecular Basis for the Regulation of Transcriptional Coactivator p300 in Myogenic Differentiation. ". Sci Rep. 2015. PMID 26354606.
• "Expanding the phenotypic spectrum in EP300-related Rubinstein-Taybi syndrome. ". Am J Med Genet A. 2015. PMID 25712426.
• "The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.". J Mol Biol. 2014. PMID 25158095.