ERCC1

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERCC1 yw ERCC1 a elwir hefyd yn DNA excision repair protein ERCC-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.32.

ERCC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Z00, 2A1I, 2A1J, 2JNW, 2JPD, 2MUT
Dynodwyr
Cyfenwau	ERCC1, COFS4, RAD10, UV20, excision repair cross-complementation group 1, ERCC excision repair 1, endonuclease non-catalytic subunit
Dynodwyr allanol	OMIM: 126380 HomoloGene: 1501 GeneCards: ERCC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • single-stranded DNA binding • damaged DNA binding • single-stranded DNA endodeoxyribonuclease activity • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • TFIID-class transcription factor complex binding • nuclease activity • endonuclease activity • hydrolase activity • 3' overhang single-stranded DNA endodeoxyribonuclease activity • DNA binding Cydrannau o'r gell • ERCC4-ERCC1 complex • transcription factor TFIID complex • nucleoplasm • nucleotide-excision repair factor 1 complex • nucleotide-excision repair complex • cnewyllyn cell • cytoplasm • cytosol Prosesau biolegol • germ cell development • DNA recombination • male gonad development • interstrand cross-link repair • positive regulation of t-circle formation • cell development • response to nutrient • multicellular organism growth • embryonic organ development • post-embryonic hemopoiesis • syncytium formation • GO:0001306 response to oxidative stress • GO:0051312, GO:0007083 chromosome organization • pyrimidine dimer repair by nucleotide-excision repair • oogenesis • cellular response to DNA damage stimulus • global genome nucleotide-excision repair • isotype switching • spermatogenesis • multicellular organism aging • UV protection • t-circle formation • negative regulation of telomere maintenance • transcription-coupled nucleotide-excision repair • mitotic recombination • cell population proliferation • nucleotide-excision repair, DNA incision • response to X-ray • response to sucrose • nucleotide-excision repair • nucleotide-excision repair, preincision complex stabilization • double-strand break repair • GO:0100026 DNA repair • nucleotide-excision repair, DNA incision, 5'-to lesion • nucleotide-excision repair, DNA incision, 3'-to lesion • meiotic mismatch repair • double-strand break repair via nonhomologous end joining • UV-damage excision repair • negative regulation of protection from non-homologous end joining at telomere • telomeric DNA-containing double minutes formation • response to immobilization stress • response to cadmium ion • nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2067	n/a
Ensembl	ENSG00000012061	n/a
UniProt	P07992	n/a
RefSeq (mRNA)	NM_001166049 NM_001983 NM_202001	n/a
RefSeq (protein)	NP_001159521 NP_001974 NP_973730 NP_001356337 NP_001356338 NP_001356339 NP_001356340 NP_001356341 NP_001356342 NP_001356343 NP_001356344 NP_001356345 NP_001356346 NP_001356347 NP_001356348	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERCC1.

• UV20
• COFS4
• RAD10

Llyfryddiaeth

• "Association between the ERCC1 polymorphism and platinum-based chemotherapy effectiveness in ovarian cancer: a meta-analysis. ". BMC Womens Health. 2017. PMID 28623887.
• "The Contribution of Excision Repair Cross-complementing Group 1 Genotypes to Colorectal Cancer Susceptibility in Taiwan. ". Anticancer Res. 2017. PMID 28476796.
• "Chemosensitizing effect of shRNA-mediated ERCC1 silencing on a Xuanwei lung adenocarcinoma cell line and its clinical significance. ". Oncol Rep. 2017. PMID 28260069.
• "Computed Tomography Manifestations and Excision Cross-Complementation Group 1 Expression of Stage I Non-Small-Cell Lung Cancer and Their Correlation With Prognosis. ". J Comput Assist Tomogr. 2016. PMID 27434787.
• "ERCC1 C118T polymorphism has predictive value for platinum-based chemotherapy in patients with late-stage bladder cancer.". Genet Mol Res. 2016. PMID 27323074.