ERN1

Protein sy'n cael ei godio yn y corff dynol gan y genyn ERN1 yw ERN1 a elwir hefyd yn Endoplasmic reticulum to nucleus signaling 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q23.3.

ERN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HZ6, 3P23, 4U6R, 4Z7G, 4Z7H, 4YZC, 4YZ9, 4YZD, 5HGI
Dynodwyr
Cyfenwau	ERN1, IRE1, IRE1P, IRE1a, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Dynodwyr allanol	OMIM: 604033 HomoloGene: 55580 GeneCards: ERN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • nucleotide binding • ADP binding • ribonuclease activity • identical protein binding • protein kinase activity • transferase activity • magnesium ion binding • hydrolase activity • Hsp70 protein binding • kinase activity • Hsp90 protein binding • catalytic activity • endonuclease activity • ATP binding • enzyme binding • GO:0001948, GO:0016582 protein binding • endoribonuclease activity • protein serine/threonine kinase activity • platelet-derived growth factor receptor binding • protein homodimerization activity • unfolded protein binding Cydrannau o'r gell • AIP1-IRE1 complex • cytoplasm • integral component of membrane • mitocondria • IRE1-TRAF2-ASK1 complex • IRE1-RACK1-PP2A complex • nuclear inner membrane • Ire1 complex • bilen • integral component of endoplasmic reticulum membrane • Reticwlwm endoplasmig • endoplasmic reticulum membrane Prosesau biolegol • positive regulation of endoplasmic reticulum unfolded protein response • mRNA catabolic process • transcription, DNA-templated • insulin metabolic process • peptidyl-serine autophosphorylation • cellular response to vascular endothelial growth factor stimulus • protein autophosphorylation • metabolaeth • GO:0097285 apoptotic process • mRNA splicing, via endonucleolytic cleavage and ligation • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • cellular response to glucose stimulus • peptidyl-serine trans-autophosphorylation • protein phosphorylation • response to unfolded protein • mRNA processing • response to endoplasmic reticulum stress • GO:0009373 regulation of transcription, DNA-templated • endothelial cell proliferation • regulation of macroautophagy • phosphorylation • endoplasmic reticulum unfolded protein response • positive regulation of vascular associated smooth muscle cell proliferation • RNA phosphodiester bond hydrolysis, endonucleolytic • positive regulation of RNA splicing • IRE1-mediated unfolded protein response • mRNA cleavage involved in mRNA processing • mRNA cleavage • Unfolded Protein Response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2081	n/a
Ensembl	ENSG00000178607	n/a
UniProt	O75460	n/a
RefSeq (mRNA)	NM_152461 NM_001433	n/a
RefSeq (protein)	NP_001424	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ERN1.

• IRE1
• IRE1P
• IRE1a
• hIRE1p

Llyfryddiaeth

• "High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence. ". Jpn J Clin Oncol. 2017. PMID 28334878.
• "Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: eff ect of IRE1 inhibition. ". Endocr Regul. 2017. PMID 28222026.
• "The UPR reduces glucose metabolism via IRE1 signaling. ". Biochim Biophys Acta. 2017. PMID 28093214.
• "IRE1α nucleotide sequence cleavage specificity in the unfolded protein response. ". FEBS Lett. 2017. PMID 28027394.
• "Structural Insights into IRE1 Functions in the Unfolded Protein Response.". Curr Med Chem. 2016. PMID 27686654.