EXOSC4

Protein sy'n cael ei godio yn y corff dynol gan y genyn EXOSC4 yw EXOSC4 a elwir hefyd yn Exosome complex component RRP41 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 8, band 8q24.3.

EXOSC4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2NN6
Dynodwyr
Cyfenwau	EXOSC4, RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A, Exosome component 4
Dynodwyr allanol	OMIM: 606491 HomoloGene: 6017 GeneCards: EXOSC4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • exoribonuclease activity • 3'-5'-exoribonuclease activity • RNA binding • mRNA 3'-UTR AU-rich region binding Cydrannau o'r gell • cytoplasmic exosome (RNase complex) • nuclear exosome (RNase complex) • cytoplasm • exosome (RNase complex) • nucleolus • cnewyllyn cell • nucleoplasm • cytosol • intermediate filament cytoskeleton Prosesau biolegol • defense response to virus • rRNA 3'-end processing • rRNA catabolic process • polyadenylation-dependent snoRNA 3'-end processing • U4 snRNA 3'-end processing • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • positive regulation of cell growth • nuclear-transcribed mRNA catabolic process • DNA deamination • maturation of 5.8S rRNA • regulation of mRNA stability • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance • exonucleolytic catabolism of deadenylated mRNA • histone mRNA catabolic process • rRNA processing • RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	54512	n/a
Ensembl	ENSG00000178896	n/a
UniProt	Q9NPD3	n/a
RefSeq (mRNA)	NM_019037	n/a
RefSeq (protein)	NP_061910	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EXOSC4.

• SKI6
• p12A
• RRP41
• Ski6p
• RRP41A
• Rrp41p
• hRrp41p

Llyfryddiaeth

• "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. ". Arthritis Res. 2002. PMID 11879549.
• "Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells. ". Proc Natl Acad Sci U S A. 2010. PMID 20368444.
• "Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. ". RNA. 2006. PMID 16912217.
• "Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. ". Nature. 2014. PMID 25043052.
• "A link between nuclear RNA surveillance, the human exosome and RNA polymerase II transcriptional termination.". Nucleic Acids Res. 2010. PMID 20699273.