EXOSC9

Protein sy'n cael ei godio yn y corff dynol gan y genyn EXOSC9 yw EXOSC9 a elwir hefyd yn Exosome complex component RRP45 ac Exosome component 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q27.

EXOSC9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2NN6
Dynodwyr
Cyfenwau	EXOSC9, PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6, Exosome component 9, PCH1D
Dynodwyr allanol	OMIM: 606180 HomoloGene: 3693 GeneCards: EXOSC9
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • 3'-5'-exoribonuclease activity • exoribonuclease activity • GO:0001948, GO:0016582 protein binding • RNA binding • mRNA 3'-UTR AU-rich region binding Cydrannau o'r gell • cytoplasm • cytosol • exosome (RNase complex) • nuclear exosome (RNase complex) • nuclear chromosome • nucleolus • extracellular exosome • cnewyllyn cell • nucleoplasm • cytoplasmic exosome (RNase complex) Prosesau biolegol • GO:0033168, GO:0036404, GO:1902360 RNA processing • regulation of mRNA stability • nuclear polyadenylation-dependent rRNA catabolic process • nuclear-transcribed mRNA catabolic process • positive regulation of cell growth • GO:0071049, GO:0071048, GO:0071033 nuclear mRNA surveillance • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • exonucleolytic catabolism of deadenylated mRNA • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • rRNA processing • exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • U1 snRNA 3'-end processing • U4 snRNA 3'-end processing • U5 snRNA 3'-end processing • nuclear polyadenylation-dependent tRNA catabolic process • nuclear polyadenylation-dependent mRNA catabolic process • rRNA catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5393	n/a
Ensembl	ENSG00000123737	n/a
UniProt	Q06265	n/a
RefSeq (mRNA)	NM_001034194 NM_005033	n/a
RefSeq (protein)	NP_001029366 NP_005024	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EXOSC9.

• p5
• p6
• RRP45
• PMSCL1
• Rrp45p
• PM/Scl-75

Llyfryddiaeth

• "The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. ". EMBO J. 2002. PMID 11782436.
• "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. ". Arthritis Res. 2002. PMID 11879549.
• "Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex. ". J Exp Med. 1991. PMID 2007859.
• "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome. ". Arthritis Rheum. 2004. PMID 14872500.
• "Adenylation and exosome-mediated degradation of cotranscriptionally cleaved pre-messenger RNA in human cells.". Mol Cell. 2006. PMID 16455498.