EZR

Protein sy'n cael ei godio yn y corff dynol gan y genyn EZR yw EZR a elwir hefyd yn Ezrin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q25.3.

EZR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4RM8, 4RMA, 4RM9, 1NI2
Dynodwyr
Cyfenwau	EZR, CVIL, CVL, HEL-S-105, VIL2, Ezrin
Dynodwyr allanol	OMIM: 123900 HomoloGene: 55740 GeneCards: EZR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • GO:0032403 protein-containing complex binding • cytoskeletal protein binding • protein kinase A regulatory subunit binding • protein kinase A catalytic subunit binding • S100 protein binding • actin filament binding • GO:0001948, GO:0016582 protein binding • cell adhesion molecule binding • microtubule binding • ATPase binding • actin binding • RNA binding • cadherin binding • protein C-terminus binding • disordered domain specific binding • protein kinase A binding • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • endosome • bilen • focal adhesion • T-tubule • ruffle • Schwann cell microvillus • ruffle membrane • actin cytoskeleton • perinuclear region of cytoplasm • Cytosgerbwd • cell projection • cytoplasmic side of apical plasma membrane • myelin sheath • microvillus • microspike • apical plasma membrane • membrane raft • extracellular exosome • microvillus membrane • ciliary basal body • filopodium • cortical cytoskeleton • Cellbilen • apical part of cell • astrocyte projection • intracellular anatomical structure • cell cortex • brush border • Microffilament • TCR signalosome • cyrion cell • cell body • fesigl • plasma membrane raft • uropod • basolateral plasma membrane • immunological synapse • cell tip • fibrillar center • extracellular space • extrinsic component of membrane • GO:0009327 protein-containing complex Prosesau biolegol • leukocyte cell-cell adhesion • regulation of organelle assembly • sphingosine-1-phosphate receptor signaling pathway • negative regulation of p38MAPK cascade • actin filament bundle assembly • establishment of epithelial cell apical/basal polarity • positive regulation of multicellular organism growth • astral microtubule organization • cellular response to cAMP • establishment of endothelial barrier • microvillus assembly • negative regulation of T cell receptor signaling pathway • gland morphogenesis • cortical microtubule organization • positive regulation of protein localization to early endosome • positive regulation of early endosome to late endosome transport • intestinal D-glucose absorption • establishment or maintenance of apical/basal cell polarity • regulation of NIK/NF-kappaB signaling • epithelial cell differentiation • regulation of actin cytoskeleton organization • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of protein secretion • membrane to membrane docking • regulation of cell shape • protein kinase A signaling • establishment of centrosome localization • phosphatidylinositol-mediated signaling • regulation of cell size • actin cytoskeleton reorganization • filopodium assembly • receptor internalization • terminal web assembly • axon guidance • GO:1901313 positive regulation of gene expression • negative regulation of ERK1 and ERK2 cascade • protein localization to cell cortex • regulation of microvillus length • protein localization to plasma membrane • positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7430	n/a
Ensembl	ENSG00000092820	n/a
UniProt	P15311	n/a
RefSeq (mRNA)	NM_001111077 NM_003379	n/a
RefSeq (protein)	NP_001104547 NP_003370	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EZR.

• CVL
• CVIL
• VIL2
• HEL-S-105

Llyfryddiaeth

• "Diagnostic Value of Autoantibodies against Ezrin in Esophageal Squamous Cell Carcinoma. ". Dis Markers. 2017. PMID 28298808.
• "Ezrin expression in the primary hepatocellular carcinoma patients and associated with clinical, pathological characteristics. ". J Cancer Res Ther. 2016. PMID 28230040.
• "Ezrin expression combined with MSI status in prognostication of stage II colorectal cancer. ". PLoS One. 2017. PMID 28953975.
• "A decision tree-based combination of ezrin-interacting proteins to estimate the prognostic risk of patients with esophageal squamous cell carcinoma. ". Hum Pathol. 2017. PMID 28603065.
• "Ezrin Ser66 phosphorylation regulates invasion and metastasis of esophageal squamous cell carcinoma cells by mediating filopodia formation.". Int J Biochem Cell Biol. 2017. PMID 28504189.