Protein sy'n cael ei godio yn y corff dynol gan y genyn NFAT5 yw NFAT5 a elwir hefyd yn Nuclear factor of-activated T-cells 5 a Nuclear factor of activated T-cells 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q22.1.[2]
NFAT5 |
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Dynodwyr |
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Cyfenwau | NFAT5, NF-AT5, NFATL1, NFATZ, OREBP, TONEBP, nuclear factor of activated T-cells 5, tonicity-responsive, nuclear factor of activated T-cells 5, nuclear factor of activated T cells 5 |
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Dynodwyr allanol | OMIM: 604708 HomoloGene: 4811 GeneCards: NFAT5 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding • transcription factor binding
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Cydrannau o'r gell | • cnewyllyn cell • nucleoplasm • cytoplasm • cytosol • transcription regulator complex
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Prosesau biolegol | • regulation of calcineurin-NFAT signaling cascade • GO:0032617 cytokine production • GO:1901313 positive regulation of gene expression • Ysgarthu • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • transcription, DNA-templated • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • calcineurin-NFAT signaling cascade • response to osmotic stress • cellular response to cytokine stimulus • positive regulation of NIK/NF-kappaB signaling • positive regulation of leukocyte adhesion to vascular endothelial cell
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn NFAT5.
- NFATZ
- OREBP
- NF-AT5
- NFATL1
- TONEBP
- "The potential role of NFAT5 and osmolarity in peritoneal injury. ". Biomed Res Int. 2015. PMID 26495302.
- "NFAT5 Is Up-Regulated by Hypoxia: Possible Implications in Preeclampsia and Intrauterine Growth Restriction. ". Biol Reprod. 2015. PMID 25995271.
- "Involvement of TonEBP/NFAT5 in osmoadaptative response of human retinal pigmented epithelial cells to hyperosmolar stress. ". Mol Vis. 2016. PMID 26912969.
- "Peptide affinity analysis of proteins that bind to an unstructured NH2-terminal region of the osmoprotective transcription factor NFAT5. ". Physiol Genomics. 2016. PMID 26757802.
- "Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence.". Transl Psychiatry. 2015. PMID 26506053.