ZBTB7A

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZBTB7A yw ZBTB7A a elwir hefyd yn Zinc finger and BTB domain containing 7A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.

ZBTB7A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2IF5, 2NN2
Dynodwyr
Cyfenwau	ZBTB7A, FBI-1, FBI1, LRF, ZBTB7, ZNF857A, pokemon, TIP21, zinc finger and BTB domain containing 7A, MNDLFH
Dynodwyr allanol	OMIM: 605878 HomoloGene: 7820 GeneCards: ZBTB7A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription corepressor binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • SMAD binding • androgen receptor binding Cydrannau o'r gell • cnewyllyn cell • cytoplasm • NuRD complex • site of double-strand break • DNA-dependent protein kinase complex Prosesau biolegol • multicellular organism development • cell differentiation • GO:0045996 negative regulation of transcription, DNA-templated • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • regulation of alternative mRNA splicing, via spliceosome • regulation of glycolytic process • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • chromatin remodeling • cellular response to DNA damage stimulus • B cell differentiation • negative regulation of transforming growth factor beta receptor signaling pathway • protein localization to nucleus • regulation of apoptotic process • erythrocyte maturation • fat cell differentiation • negative regulation of Notch signaling pathway • regulation of DNA-binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity • negative regulation of androgen receptor signaling pathway • double-strand break repair via classical nonhomologous end joining • regulation of transcription regulatory region DNA binding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51341	n/a
Ensembl	ENSG00000178951	n/a
UniProt	O95365	n/a
RefSeq (mRNA)	NM_015898 NM_001317990 NM_020224	n/a
RefSeq (protein)	NP_001304919 NP_056982	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZBTB7A.

• LRF
• FBI1
• FBI-1
• TIP21
• ZBTB7
• ZNF857A
• pokemon

Llyfryddiaeth

• "Pokemon enhances proliferation, cell cycle progression and anti-apoptosis activity of colorectal cancer independently of p14ARF-MDM2-p53 pathway. ". Med Oncol. 2014. PMID 25367850.
• "ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. ". Genes Dev. 2014. PMID 25184678.
• "LRF inhibits p53 expression in colon cancer cells via modulating DAP5 activity. ". Cell Biochem Funct. 2017. PMID 28849590.
• "Somatic human ZBTB7A zinc finger mutations promote cancer progression. ". Oncogene. 2016. PMID 26455326.
• "Pokemon proto-oncogene in oral cancer: potential role in the early phase of tumorigenesis.". Oral Dis. 2015. PMID 25439053.