ZFP36

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZFP36 yw ZFP36 a elwir hefyd yn ZFP36 ring finger protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.2.

ZFP36
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4J8S
Dynodwyr
Cyfenwau	ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36, ZFP36 ring finger protein
Dynodwyr allanol	OMIM: 190700 HomoloGene: 2558 GeneCards: ZFP36
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • C-C chemokine binding • 14-3-3 protein binding • metal ion binding • GO:0001948, GO:0016582 protein binding • single-stranded RNA binding • mRNA 3'-UTR AU-rich region binding • enzyme binding • mRNA binding • protein kinase binding • RNA binding • heat shock protein binding • RNA polymerase binding • mRNA 3'-UTR binding Cydrannau o'r gell • cytoplasm • cytoplasmic stress granule • cnewyllyn cell • RISC-loading complex • ribonucleoprotein complex • Dcp1-Dcp2 complex • exosome (RNase complex) • P-body • cytosol • CCR4-NOT complex Prosesau biolegol • nuclear-transcribed mRNA poly(A) tail shortening • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • mRNA catabolic process • regulation of tumor necrosis factor production • GO:1901227 negative regulation of transcription by RNA polymerase II • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • miRNA-mediated gene silencing by inhibition of translation • response to starvation • 3'-UTR-mediated mRNA stabilization • negative regulation of erythrocyte differentiation • cellular response to lipopolysaccharide • cellular response to tumor necrosis factor • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA • regulation of keratinocyte apoptotic process • regulation of keratinocyte proliferation • positive regulation of fat cell differentiation • cellular response to fibroblast growth factor stimulus • cellular response to granulocyte macrophage colony-stimulating factor stimulus • negative regulation of viral transcription • regulation of keratinocyte differentiation • response to wounding • GO:1905618 positive regulation of gene silencing by miRNA • regulation of mRNA stability • MAPK cascade • cellular response to glucocorticoid stimulus • cellular response to epidermal growth factor stimulus • positive regulation of intracellular mRNA localization • p38MAPK cascade • nuclear-transcribed mRNA catabolic process, deadenylation-independent decay • gene silencing • mRNA transport • 3'-UTR-mediated mRNA destabilization • negative regulation of polynucleotide adenylyltransferase activity • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7538	n/a
Ensembl	ENSG00000128016	n/a
UniProt	P26651	n/a
RefSeq (mRNA)	NM_003407	n/a
RefSeq (protein)	NP_003398	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZFP36.

• TTP
• G0S24
• GOS24
• TIS11
• NUP475
• zfp-36
• RNF162A

Llyfryddiaeth

• "The Expression of Tristetraprolin and Its Relationship with Urinary Proteins in Patients with Diabetic Nephropathy. ". PLoS One. 2015. PMID 26517838.
• "Global target mRNA specification and regulation by the RNA-binding protein ZFP36. ". Genome Biol. 2014. PMID 24401661.
• "Tristetraprolin regulates the decay of the hypoxia-induced vascular endothelial growth factor mRNA in ARPE-19 cells. ". Mol Med Rep. 2016. PMID 27840917.
• "Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells. ". Cell Signal. 2016. PMID 26820662.
• "Three Residues Make an Evolutionary Switch for Folding and RNA-Destabilizing Activity in the TTP Family of Proteins.". ACS Chem Biol. 2016. PMID 26551835.