ABL2

Protein sy'n cael ei godio yn y corff dynol gan y genyn ABL2 yw ABL2 a elwir hefyd yn ABL proto-oncogene 2, non-receptor tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q25.2.

ABL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH
Dynodwyr
Cyfenwau	ABL2, ABLL, ARG, ABL proto-oncogene 2, non-receptor tyrosine kinase
Dynodwyr allanol	OMIM: 164690 HomoloGene: 5278 GeneCards: ABL2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • actin monomer binding • manganese ion binding • non-membrane spanning protein tyrosine kinase activity • metal ion binding • kinase activity • actin filament binding • GO:0001948, GO:0016582 protein binding • signaling receptor binding • ATP binding • magnesium ion binding • protein tyrosine kinase activity • phosphotyrosine residue binding Cydrannau o'r gell • cytoplasm • cytosol • extrinsic component of cytoplasmic side of plasma membrane • actin cytoskeleton • Cytosgerbwd Prosesau biolegol • cellular response to retinoic acid • regulation of actin cytoskeleton reorganization • phosphorylation • positive regulation of phospholipase C activity • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cytosolic calcium ion concentration • GO:1900490 positive regulation of oxidoreductase activity • regulation of cell motility • protein phosphorylation • cell adhesion • regulation of cell population proliferation • positive regulation of neuron projection development • peptidyl-tyrosine autophosphorylation • peptidyl-tyrosine phosphorylation • innate immune response • GO:0072468 signal transduction • regulation of autophagy • regulation of endocytosis • regulation of cell adhesion • cell differentiation • negative regulation of Rho protein signal transduction • exploration behavior Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	27	n/a
Ensembl	ENSG00000143322	n/a
UniProt	P42684	n/a
RefSeq (mRNA)	NM_001136000 NM_001136001 NM_001168236 NM_001168237 NM_001168238 NM_001168239 NM_005158 NM_007314	n/a
RefSeq (protein)	NP_001129472 NP_001129473 NP_001161708 NP_001161709 NP_001161710 NP_001161711 NP_005149 NP_009298	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ABL2.

• ARG
• ABLL

Llyfryddiaeth

• "One isoform of Arg/Abl2 tyrosine kinase is nuclear and the other seven cytosolic isoforms differently modulate cell morphology, motility and the cytoskeleton. ". Exp Cell Res. 2013. PMID 23707396.
• "Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. ". Oncogene. 2013. PMID 22777352.
• "Knockout mutation of p27-p55 operon severely reduces replication of Mycobacterium bovis in a macrophagic cell line and survival in a mouse model of infection. ". Virulence. 2011. PMID 21543883.
• "Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS. ". Blood. 2010. PMID 20448119.
• "NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens.". Proteins. 2010. PMID 20077570.