ACE

ACE
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1O86, 1O8A, 1UZE, 1UZF, 2C6F, 2C6N, 2IUL, 2IUX, 2OC2, 2XY9, 2XYD, 2YDM, 3BKK, 3BKL, 3NXQ, 4APH, 4APJ, 3L3N, 4BXK, 4BZR, 4BZS, 4C2N, 4C2O, 4C2P, 4C2Q, 4C2R, 4CA5, 4CA6, 4UFA, 4UFB, 5AMB, 5AM9, 5AM8, 5AMC, 5AMA
Dynodwyr
Cyfenwau	ACE, angiotensin I converting enzyme, ACE1, CD143, DCP, DCP1, ICH, MVCD3, Angiotensin-converting enzyme
Dynodwyr allanol	OMIM: 106180 HomoloGene: 37351 GeneCards: ACE
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• tripeptidyl-peptidase activity; • zinc ion binding; • exopeptidase activity; • endopeptidase activity; • metal ion binding; • mitogen-activated protein kinase binding; • bradykinin receptor binding; • GO:0070122 peptidase activity; • GO:0001948, GO:0016582 protein binding; • carboxypeptidase activity; • chloride ion binding; • actin binding; • mitogen-activated protein kinase kinase binding; • hydrolase activity; • metallodipeptidase activity; • metallopeptidase activity; • peptidyl-dipeptidase activity; • dipeptidyl-peptidase activity;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • endosome; • bilen; • lysosome; • extracellular exosome; • external side of plasma membrane; • extracellular region; • Cellbilen; • extracellular space;
Prosesau biolegol	• regulation of renal output by angiotensin; • antigen processing and presentation of peptide antigen via MHC class I; • amyloid-beta metabolic process; • angiotensin maturation; • blood vessel remodeling; • regulation of vasoconstriction; • hematopoietic stem cell differentiation; • regulation of angiotensin metabolic process; • regulation of smooth muscle cell migration; • mononuclear cell proliferation; • regulation of systemic arterial blood pressure by renin-angiotensin; • arachidonic acid secretion; • peptide catabolic process; • blood vessel diameter maintenance; • proteolysis; • kidney development; • neutrophil mediated immunity; • positive regulation of systemic arterial blood pressure; • spermatogenesis; • regulation of blood pressure; • posttranscriptional regulation of gene expression; • negative regulation of gene expression; • negative regulation of protein binding; • positive regulation of protein binding; • hormone catabolic process; • heart contraction; • positive regulation of protein tyrosine kinase activity; • cell proliferation in bone marrow; • positive regulation of peptidyl-tyrosine autophosphorylation; • regulation of hematopoietic stem cell proliferation; • negative regulation of gap junction assembly; • positive regulation of peptidyl-cysteine S-nitrosylation; • positive regulation of blood pressure;
	Sources:Amigo / QuickGO
Orthologau
	1636
	n/a
	ENSG00000159640
	n/a
	P12821
	n/a
NM_000789; NM_001178057; NM_152830; NM_152831; NM_001382700;
	NM_001382701; NM_001382702
	n/a
NP_000780; NP_001171528; NP_690043; NP_001369629; NP_001369630;
	NP_001369631
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ACE yw ACE a elwir hefyd yn Angiotensin I converting enzyme (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ACE.

DCP
ACE1
DCP1
CD143

Llyfryddiaeth

"Angiotensin-Converting Enzyme ID Polymorphism in Patients with Heart Failure Secondary to Chagas Disease. ". Arq Bras Cardiol. 2017. PMID 28977050.
"Assessment of the rs4340 ACE gene polymorphism in acute coronary syndrome in a Western Mexican population. ". Genet Mol Res. 2017. PMID 28973758.
"ACE Phenotyping as a Guide Toward Personalized Therapy With ACE Inhibitors. ". J Cardiovasc Pharmacol Ther. 2017. PMID 28587581.
"(-)-Epigallocatechin-3-gallate inhibits human angiotensin-converting enzyme activity through an autoxidation-dependent mechanism. ". J Biochem Mol Toxicol. 2017. PMID 28544013.
"Relationship of Serum Klotho Level With ACE Gene Polymorphism in Stable Kidney Allograft Recipients.". Iran J Kidney Dis. 2017. PMID 28270648.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ACE - Cronfa NCBI

[2]

[1]