ACVR2B

ACVR2B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2QLU, 4FAO, 2H62
Dynodwyr
Cyfenwau	ACVR2B, ACTRIIB, ActR-IIB, HTX4, activin A receptor type 2B
Dynodwyr allanol	OMIM: 602730 HomoloGene: 863 GeneCards: ACVR2B
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • growth factor binding; • activin binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • transmembrane receptor protein serine/threonine kinase activity; • GO:0001948, GO:0016582 protein binding; • protein serine/threonine/tyrosine kinase activity; • activin receptor activity, type II; • ATP binding; • transforming growth factor beta-activated receptor activity; • transforming growth factor beta receptor activity, type II; • type I transforming growth factor beta receptor binding; • SMAD binding;
Cydrannau o'r gell	• cytoplasm; • integral component of membrane; • bilen; • receptor complex; • Cellbilen; • integral component of plasma membrane; • GO:0009327 protein-containing complex; • activin receptor complex;
Prosesau biolegol	• pattern specification process; • skeletal system development; • roof of mouth development; • GO:0009373 regulation of transcription, DNA-templated; • organ growth; • embryonic foregut morphogenesis; • kidney development; • lymphangiogenesis; • lung development; • positive regulation of bone mineralization; • retina vasculature development in camera-type eye; • phosphorylation; • lymphatic endothelial cell differentiation; • skeletal system morphogenesis; • gastrulation with mouth forming second; • insulin secretion; • GO:1901227 negative regulation of transcription by RNA polymerase II; • response to glucose; • post-embryonic development; • BMP signaling pathway; • venous blood vessel development; • odontogenesis of dentin-containing tooth; • protein phosphorylation; • heart development; • blood vessel remodeling; • determination of left/right symmetry; • positive regulation of osteoblast differentiation; • transmembrane receptor protein serine/threonine kinase signaling pathway; • positive regulation of activin receptor signaling pathway; • regulation of signal transduction; • artery development; • pancreas development; • mesoderm development; • activation of protein kinase activity; • GO:0072468 signal transduction; • anterior/posterior pattern specification; • activin receptor signaling pathway; • transforming growth factor beta receptor signaling pathway; • negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologau
	93
	n/a
	ENSG00000114739
	n/a
	Q13705
	n/a
	NM_001106
	n/a
	NP_001097
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ACVR2B yw ACVR2B a elwir hefyd yn Activin A receptor type 2B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ACVR2B.

HTX4
ACTRIIB
ActR-IIB

Llyfryddiaeth

"Genetic Variant in ACVR2B Is Associated with Lean Mass. ". Med Sci Sports Exerc. 2016. PMID 26848890.
"miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms. ". Carcinogenesis. 2012. PMID 22431721.
"Crystal structure of activin receptor type IIB kinase domain. ". Vitam Horm. 2011. PMID 21353874.
"Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type. ". J Appl Physiol (1985). 2010. PMID 20466801.
"Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution.". Protein Sci. 2007. PMID 17893364.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ACVR2B - Cronfa NCBI

[2]

[1]