AGO1

Protein sy'n cael ei godio yn y corff dynol gan y genyn AGO1 yw AGO1 a elwir hefyd yn Argonaute 1, RISC catalytic component (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p34.3.

AGO1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1SI2, 1SI3, 4KRE, 4KRF, 4KXT
Dynodwyr
Cyfenwau	AGO1, EIF2C, EIF2C1, GERP95, Q99, hAgo1, argonaute 1, RISC catalytic component, argonaute RISC catalytic component 1, argonaute RISC component 1
Dynodwyr allanol	OMIM: 606228 HomoloGene: 81826 GeneCards: AGO1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • RNA polymerase II complex binding • miRNA binding • endoribonuclease activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • single-stranded RNA binding • RNA binding • nucleic acid binding • double-stranded RNA binding Cydrannau o'r gell • cytoplasm • polysome • cytosol • RISC complex • P-body • nucleoplasm • RISC-loading complex • cnewyllyn cell • ribonucleoprotein complex Prosesau biolegol • mRNA destabilization-mediated gene silencing by siRNA • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • pre-miRNA processing • nuclear-transcribed mRNA catabolic process • GO:1901313 positive regulation of gene expression • GO:0035194 RNA interference • miRNA-mediated gene silencing by inhibition of translation • RNA secondary structure unwinding • mRNA destabilization-mediated gene silencing by miRNA • GO:0061715 miRNA metabolic process • regulation of translation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • production of miRNAs involved in gene silencing by miRNA • positive regulation of NIK/NF-kappaB signaling • Wnt signaling pathway, calcium modulating pathway • gene silencing • GO:1905616 regulation of gene silencing by miRNA • regulation of megakaryocyte differentiation • negative regulation of gene expression • negative regulation of angiogenesis • RNA phosphodiester bond hydrolysis, endonucleolytic Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	26523	n/a
Ensembl	ENSG00000092847	n/a
UniProt	Q9UL18	n/a
RefSeq (mRNA)	NM_012199 NM_001317122 NM_001317123	n/a
RefSeq (protein)	NP_001304051 NP_001304052 NP_036331	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AGO1.

• Q99
• EIF2C
• hAgo1
• EIF2C1
• GERP95

Llyfryddiaeth

• "Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. ". Nature. 2004. PMID 15152257.
• "Multivalent Recruitment of Human Argonaute by GW182. ". Mol Cell. 2017. PMID 28781232.
• "Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells. ". Proc Natl Acad Sci U S A. 2014. PMID 25313066.
• "The making of a slicer: activation of human Argonaute-1. ". Cell Rep. 2013. PMID 23746446.
• "Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets.". Genome Res. 2009. PMID 19767416.