AIF1

AIF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2D58, 2G2B
Dynodwyr
Cyfenwau	AIF1, AIF-1, IBA1, IRT-1, IRT1, allograft inflammatory factor 1, Iba-1
Dynodwyr allanol	OMIM: 601833 HomoloGene: 1226 GeneCards: AIF1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • metal ion binding; • actin filament binding; • actin binding; • molecular function;
Cydrannau o'r gell	• cytoplasm; • cytosol; • perikaryon; • cell projection; • bilen; • ruffle; • Cellbilen; • ruffle membrane; • Microffilament; • perinuclear region of cytoplasm; • phagocytic cup; • Cytosgerbwd; • cnewyllyn cell; • lamellipodium;
Prosesau biolegol	• cellular response to extracellular stimulus; • positive regulation of smooth muscle cell chemotaxis; • response to cytokine; • positive regulation of protein phosphorylation; • negative regulation of smooth muscle cell proliferation; • positive regulation of cell migration; • positive regulation of muscle hyperplasia; • positive regulation of nitric oxide biosynthetic process; • positive regulation of monocyte chemotaxis; • negative regulation of apoptotic process; • response to glucocorticoid; • response to electrical stimulus; • negative regulation of gene expression; • cellular response to hydroperoxide; • actin filament bundle assembly; • microglial cell activation; • positive regulation of G1/S transition of mitotic cell cycle; • actin filament polymerization; • negative regulation of smooth muscle cell chemotaxis; • cellular response to hormone stimulus; • phagocytosis, engulfment; • response to axon injury; • positive regulation of T cell proliferation; • cellular response to interferon-gamma; • cellular response to morphine; • Rac protein signal transduction; • inflammatory response; • ruffle assembly; • positive regulation of T cell migration; • positive regulation of smooth muscle cell proliferation; • cerebellum development; • positive regulation of cell population proliferation; • regulation of gene expression; • parallel actin filament bundle assembly; • cellular response to oxidative stress; • positive regulation of chemotaxis; • actin crosslink formation; • positive regulation of mononuclear cell migration; • positive regulation of fibroblast growth factor production;
	Sources:Amigo / QuickGO
Orthologau
	199
	n/a
ENSG00000206428; ENSG00000235985; ENSG00000235588; ENSG00000234836; ENSG00000237727;
	ENSG00000204472
	n/a
	P55008; Q4V347
	n/a
	NM_001623; NM_004847; NM_032955; NM_001318970
	n/a
	NP_001305899; NP_001614; NP_116573; NP_001614.3
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AIF1 yw AIF1 a elwir hefyd yn Allograft inflammatory factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AIF1.

IBA1
IRT1
AIF-1
IRT-1

Llyfryddiaeth

"Expression of allograft inflammatory factor-1 in peripheral blood monocytes and synovial membranes in patients with rheumatoid arthritis. ". Hum Immunol. 2016. PMID 26585362.
"Influence of AIF1 Gene Polymorphisms on Long-Term Kidney Allograft Function. ". Ann Transplant. 2015. PMID 26324213.
"[Association between AIF-1 gene polymorphisms and response to rheumatoid arthritis treatment with sulphasalazine]. ". Ann Acad Med Stetin. 2013. PMID 25026748.
"Allograft inflammatory factor-1 stimulates chemokine production and induces chemotaxis in human peripheral blood mononuclear cells. ". Biochem Biophys Res Commun. 2014. PMID 24796669.
"Allograft inflammatory factor-1 is an independent prognostic indicator that regulates β-catenin in gastric cancer.". Oncol Rep. 2014. PMID 24337893.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AIF1 - Cronfa NCBI

[2]

[1]