AKR1B1

AKR1B1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2PDQ, 1IEI, 2ACQ, 2FZB, 2IKH, 2PDH, 3LD5, 2IQ0, 1T40, 2PDG, 2PDB, 3GHR, 2NVD, 2PD5, 2PDU, 3M4H, 4GCA, 2PDX, 2I17, 1US0, 1AZ1, 2R24, 3M64, 1MAR, 3ONC, 1Z3N, 3ONB, 2ACR, 2DUZ, 2DUX, 2HVO, 2FZ8, 4PUW, 4XZH, 4QBX, 4JIR, 2PD9, 3LQL, 1ABN, 2PDW, 4PR4, 2PDI, 3LEP, 2PDJ, 4PUU, 2DV0, 3LEN, 3G5E, 1EF3, 4LB3, 2PDC, 3LBO, 2PDP, 2FZD, 4NKC, 2PZN, 2ISF, 3RX4, 2PDL, 3Q65, 4PRT, 4Q7B, 4QX4, 2FZ9, 2IKJ, 2J8T, 4IGS, 2IS7, 3V35, 1Z8A, 1XGD, 3T42, 2QXW, 4QR6, 1X96, 4RPQ, 2HV5, 2NVC, 2F2K, 3BCJ, 3LZ3, 3V36, 2PDK, 3GHU, 3GHS, 2ACU, 2PDM, 4LAZ, 1T41, 2IKG, 3MB9, 2PDF, 4PRR, 2PDN, 3LQG, 4XZI, 3LZ5, 2AGT, 3S3G, 1PWL, 3M0I, 2PF8, 3RX2, 2IPW, 3MC5, 3DN5, 4QXI, 2HVN, 2INZ, 1X97, 2PDY, 3RX3, 1PWM, 4LBR, 3Q67, 4LAU, 1Z89, 2IKI, 3P2V, 1X98, 1AZ2, 2PFH, 3U2C, 2ACS, 3GHT, 4LB4, 2INE, 1EL3, 2I16, 2IQD, 2PEV, 4LBS, 1ADS, 4YU1, 4YS1
Dynodwyr
Cyfenwau	AKR1B1, ADR, ALDR1, ALR2, AR, aldo-keto reductase family 1, member B1 (aldose reductase), aldo-keto reductase family 1 member B
Dynodwyr allanol	OMIM: 103880 HomoloGene: 133743 GeneCards: AKR1B1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• aldo-keto reductase (NADP) activity; • electron transfer activity; • oxidoreductase activity; • glyceraldehyde oxidoreductase activity; • alditol:NADP+ 1-oxidoreductase activity; • alcohol dehydrogenase (NADP+) activity; • retinal dehydrogenase activity; • allyl-alcohol dehydrogenase activity; • NADP-retinol dehydrogenase activity;
Cydrannau o'r gell	• mast cell granule; • Schwann cell microvillus; • Schmidt-Lanterman incisure; • nucleoplasm; • plasma membrane bounded cell projection cytoplasm; • perinuclear region of cytoplasm; • paranodal junction; • extracellular exosome; • extracellular space; • cytoplasm; • cytosol;
Prosesau biolegol	• stress-activated protein kinase signaling cascade; • cellular response to peptide; • daunorubicin metabolic process; • doxorubicin metabolic process; • maternal process involved in female pregnancy; • monosaccharide metabolic process; • norepinephrine metabolic process; • fructose biosynthetic process; • response to thyroid hormone; • response to stress; • response to water deprivation; • cellular response to methylglyoxal; • response to organic substance; • C21-steroid hormone biosynthetic process; • tissue homeostasis; • inner medullary collecting duct development; • positive regulation of receptor signaling pathway via JAK-STAT; • positive regulation of smooth muscle cell proliferation; • cellular response to hydrogen peroxide; • sorbitol biosynthetic process; • renal water homeostasis; • regulation of urine volume; • negative regulation of apoptotic process; • renal system development; • carbohydrate metabolic process; • electron transport chain; • cellular hyperosmotic salinity response; • retinoid metabolic process; • metanephric collecting duct development; • retinol metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	231
	n/a
	ENSG00000085662
	n/a
	P15121
	n/a
	NM_001628; NM_001346142
	n/a
	NP_001333071; NP_001619
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1B1 yw AKR1B1 a elwir hefyd yn Aldo-keto reductase family 1 member B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q33.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1B1.

AR
ADR
ALR2
ALDR1

Llyfryddiaeth

"AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program. ". J Exp Med. 2017. PMID 28270406.
"Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations. ". Cell Commun Signal. 2017. PMID 28057038.
"Association of aldose reductase gene (AKR1B1) polymorphism with diabetic retinopathy. ". Diabetes Res Clin Pract. 2016. PMID 27640118.
"Aldose reductase C-106T polymorphism is associated with the risk of essential hypertension. ". Gene. 2016. PMID 27343777.
"Association of the Aldose Reductase-106TT Genotype with Increased Risk for Diabetic Retinopathy in the Chinese Han Population: An Updated Meta-Analysis.". Curr Eye Res. 2016. PMID 26580232.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AKR1B1 - Cronfa NCBI

[2]

[1]