AKR1C3

AKR1C3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1RY0, 1RY8, 1S1P, 1S1R, 1S2A, 1S2C, 1XF0, 1ZQ5, 2F38, 2FGB, 3R43, 3R58, 3R6I, 3R7M, 3R8G, 3R8H, 3R94, 3UFY, 3UG8, 3UGR, 3UWE, 4DBS, 4DBU, 4DBW, 4DZ5, 4FA3, 4FAL, 4FAM, 4H7C, 4HMN, 4WDT, 4WDU, 4WDW, 4WDX, 4WRH, 4XVD, 4XVE, 4ZFC, 4YVX, 4YVV
Dynodwyr
Cyfenwau	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS, aldo-keto reductase family 1, member C3, aldo-keto reductase family 1 member C3
Dynodwyr allanol	OMIM: 603966 HomoloGene: 128661 GeneCards: AKR1C3
EC number	1.3.1.20
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• delta4-3-oxosteroid 5beta-reductase activity; • prostaglandin-F synthase activity; • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity; • alditol:NADP+ 1-oxidoreductase activity; • retinal dehydrogenase activity; • geranylgeranyl reductase activity; • indanol dehydrogenase activity; • aldo-keto reductase (NADP) activity; • dihydrotestosterone 17-beta-dehydrogenase activity; • phenanthrene 9,10-monooxygenase activity; • ketoreductase activity; • oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; • testosterone dehydrogenase (NAD+) activity; • NAD-retinol dehydrogenase activity; • testosterone 17-beta-dehydrogenase (NADP+) activity; • oxidoreductase activity; • androsterone dehydrogenase activity; • 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity; • ketosteroid monooxygenase activity; • NADP-retinol dehydrogenase activity; • prostaglandin D2 11-ketoreductase activity; • prostaglandin H2 endoperoxidase reductase activity; • alcohol dehydrogenase (NADP+) activity; • steroid dehydrogenase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • intracellular anatomical structure; • extracellular exosome; • cnewyllyn cell;
Prosesau biolegol	• cellular response to calcium ion; • negative regulation of retinoic acid biosynthetic process; • prostaglandin metabolic process; • G protein-coupled receptor signaling pathway; • cellular response to jasmonic acid stimulus; • steroid metabolic process; • positive regulation of protein kinase B signaling; • male gonad development; • positive regulation of cell death; • daunorubicin metabolic process; • doxorubicin metabolic process; • response to nutrient; • regulation of retinoic acid receptor signaling pathway; • progesterone metabolic process; • cellular response to starvation; • regulation of testosterone biosynthetic process; • cellular response to cadmium ion; • cellular response to corticosteroid stimulus; • cyclooxygenase pathway; • keratinocyte differentiation; • retinal metabolic process; • retinoid metabolic process; • GO:0072353 cellular response to reactive oxygen species; • farnesol catabolic process; • positive regulation of endothelial cell apoptotic process; • positive regulation of reactive oxygen species metabolic process; • cellular response to prostaglandin D stimulus; • positive regulation of cell population proliferation; • renal absorption; • testosterone biosynthetic process; • cellular response to prostaglandin stimulus; • retinol metabolic process; • macromolecule metabolic process;
	Sources:Amigo / QuickGO
Orthologau
	8644
	n/a
	ENSG00000196139
	n/a
	P42330
	n/a
	NM_003739; NM_001253908; NM_001253909; NM_016253
	n/a
	NP_001240837; NP_001240838; NP_003730
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKR1C3 yw AKR1C3 a elwir hefyd yn Aldo-keto reductase family 1 member C3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p15.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKR1C3.

DD3
DDX
PGFS
HAKRB
HAKRe
HA1753
HSD17B5
hluPGFS

Llyfryddiaeth

"Association of AKR1C3 Polymorphisms with Bladder Cancer. ". Urol J. 2016. PMID 27085562.
"A Single Nucleotide Variant in the Promoter Region of 17β-HSD Type 5 Gene Influences External Genitalia Virilization in Females with 21-Hydroxylase Deficiency. ". Horm Res Paediatr. 2016. PMID 27082632.
"Instability of C154Y variant of aldo-keto reductase 1C3. ". Chem Biol Interact. 2017. PMID 28025170.
"Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?". BMC Urol. 2016. PMID 27485119.
"Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases.". Pharmacogenet Genomics. 2016. PMID 27111237.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AKR1C3 - Cronfa NCBI

[2]

[1]