AKT2

Protein sy'n cael ei godio yn y corff dynol gan y genyn AKT2 yw AKT2 a elwir hefyd yn RAC-beta serine/threonine-protein kinase ac AKT serine/threonine kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19q13.2.

AKT2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D
Dynodwyr
Cyfenwau	AKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
Dynodwyr allanol	OMIM: 164731 HomoloGene: 48773 GeneCards: AKT2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • metal ion binding Cydrannau o'r gell • cytoplasm • endosome • bilen • Cellbilen • nucleoplasm • ruffle membrane • cell cortex • early endosome • cnewyllyn cell • cytosol • intracellular membrane-bounded organelle • GO:0009327 protein-containing complex • intracellular anatomical structure Prosesau biolegol • positive regulation of protein targeting to membrane • GO:0097285 apoptotic process • positive regulation of fatty acid beta-oxidation • GO:1901047 insulin receptor signaling pathway • positive regulation of protein phosphorylation • GO:0007243 intracellular signal transduction • regulation of cell migration • peripheral nervous system myelin maintenance • positive regulation of glycogen biosynthetic process • positive regulation of cell motility • intracellular protein transmembrane transport • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • phosphorylation • positive regulation of glucose metabolic process • mammary gland epithelial cell differentiation • multicellular organism development • protein phosphorylation • negative regulation of long-chain fatty acid import across plasma membrane • glycogen biosynthetic process • positive regulation of vesicle fusion • GO:0035404 peptidyl-serine phosphorylation • glucose metabolic process • cellular response to insulin stimulus • glycogen metabolic process • protein localization to plasma membrane • regulation of translation • fat cell differentiation • GO:0072468 signal transduction • GO:0006859 carbohydrate transport • positive regulation of cell migration • positive regulation of glucose import • cellular response to high light intensity • retinal rod cell apoptotic process • positive regulation of cell population proliferation • positive regulation of mitochondrial membrane potential • negative regulation of apoptotic process • carbohydrate metabolic process • protein kinase B signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	208	n/a
Ensembl	ENSG00000105221	n/a
UniProt	P31751	n/a
RefSeq (mRNA)	NM_001243027 NM_001243028 NM_001626 NM_001330511	n/a
RefSeq (protein)	NP_001229956 NP_001229957 NP_001317440 NP_001617	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AKT2.

• PKBB
• PRKBB
• HIHGHH
• PKBBETA
• RAC-BETA

Llyfryddiaeth

• "Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia. ". J Clin Endocrinol Metab. 2017. PMID 28541532.
• "A Low-Frequency Inactivating AKT2Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. ". Diabetes. 2017. PMID 28341696.
• "A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) Domain. ". PLoS One. 2016. PMID 28036396.
• "Hypermethylation of AKT2 gene is associated with neural-tube defects in fetus. ". Placenta. 2016. PMID 27871477.
• "Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation.". Sci Rep. 2015. PMID 26234648.