ALK

Protein sy'n cael ei godio yn y corff dynol gan y genyn ALK yw ALK a elwir hefyd yn ALK receptor tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p23.2-p23.1.

ALK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2KUP, 2KUQ, 2XB7, 2XBA, 2XP2, 2YFX, 2YHV, 2YJR, 2YJS, 2YS5, 2YT2, 3AOX, 3L9P, 3LCS, 3LCT, 4ANL, 4ANQ, 4ANS, 4CCB, 4CCU, 4CD0, 4CLI, 4CLJ, 4CMO, 4CMT, 4CMU, 4CNH, 4CTB, 4CTC, 4DCE, 4FNW, 4FNX, 4FNY, 4FNZ, 4FOB, 4FOD, 4JOA, 4MKC, 4TT7, 4Z55, 5FTO, 5AAB, 5AAA, 5J7H, 5AA9, 5IUH, 5IUI, 5IMX, 5FTQ, 5A9U, 5IUG, 5AA8, 5AAC
Dynodwyr
Cyfenwau	ALK, CD246, NBLST3, anaplastic lymphoma receptor tyrosine kinase, ALK receptor tyrosine kinase, ALK (gene), ALK1
Dynodwyr allanol	OMIM: 105590 HomoloGene: 68387 GeneCards: ALK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • kinase activity • NF-kappaB-inducing kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • ATP binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity Cydrannau o'r gell • integral component of membrane • bilen • extracellular exosome • integral component of plasma membrane • intracellular anatomical structure • Cellbilen • GO:0009327 protein-containing complex • receptor complex Prosesau biolegol • regulation of apoptotic process • transmembrane receptor protein tyrosine kinase signaling pathway • nervous system development • protein phosphorylation • positive regulation of NF-kappaB transcription factor activity • cell population proliferation • protein autophosphorylation • GO:0072468 signal transduction • neuron development • peptidyl-tyrosine phosphorylation • NIK/NF-kappaB signaling • phosphorylation • brain development • hippocampus development • adult behavior • swimming behavior • regulation of cell population proliferation • regulation of dopamine receptor signaling pathway • response to environmental enrichment • regulation of neuron differentiation • positive regulation of dendrite development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	238	n/a
Ensembl	ENSG00000171094	n/a
UniProt	Q9UM73	n/a
RefSeq (mRNA)	NM_004304 NM_001353765	n/a
RefSeq (protein)	NP_004295 NP_001340694	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ALK.

• CD246
• NBLST3

Llyfryddiaeth

• "The role of anaplastic lymphoma kinase in pediatric cancers. ". Cancer Sci. 2017. PMID 28756644.
• "Anaplastic lymphoma kinase-positive large B-cell lymphoma: Clinico-pathological study of 17 cases with review of literature. ". PLoS One. 2017. PMID 28665943.
• "RT-PCR for Detecting ALK Translocations in Cytology Samples from Lung Cancer Patients. ". Anticancer Res. 2017. PMID 28551680.
• "Circulating Tumor Cells with Aberrant ALKCopy Number Predict Progression-Free Survival during Crizotinib Treatment in ALK-Rearranged Non-Small Cell Lung Cancer Patients. ". Cancer Res. 2017. PMID 28461563.
• "ALK rearrangement in specific subtypes of lung adenocarcinoma: immunophenotypic and morphological features.". Med Oncol. 2017. PMID 28364271.