ALOX12

ALOX12
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3D3L
Dynodwyr
Cyfenwau	ALOX12, 12-LOX, 12S-LOX, LOG12, arachidonate 12-lipoxygenase, 12S type
Dynodwyr allanol	OMIM: 152391 HomoloGene: 560 GeneCards: ALOX12
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hepoxilin A3 synthase activity; • iron ion binding; • arachidonate 12(S)-lipoxygenase activity; • dioxygenase activity; • hepoxilin-epoxide hydrolase activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • linoleate 13S-lipoxygenase activity; • oxidoreductase activity; • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; • hydrolase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • sarcolemma; • extracellular exosome;
Prosesau biolegol	• linoleic acid metabolic process; • positive regulation of cell death; • positive regulation of endothelial cell differentiation; • establishment of skin barrier; • lipoxin A4 biosynthetic process; • lipid metabolism; • positive regulation of cell migration; • lipoxin B4 biosynthetic process; • GO:0010260 heneiddio; • negative regulation of apoptotic process; • negative regulation of platelet aggregation; • negative regulation of muscle cell apoptotic process; • fatty acid metabolic process; • positive regulation of angiogenesis; • reactive oxygen species metabolic process; • superoxide anion generation; • positive regulation of endothelial cell migration; • lipoxygenase pathway; • hepoxilin biosynthetic process; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of cell growth; • GO:1901313 positive regulation of gene expression; • leukotriene A4 metabolic process; • positive regulation of mitochondrial depolarization; • fatty acid oxidation; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • cellular response to lipid; • hepoxilin metabolic process; • lipoxin metabolic process; • positive regulation of cell adhesion; • positive regulation of smooth muscle cell proliferation; • arachidonic acid metabolic process; • long-chain fatty acid biosynthetic process; • positive regulation of blood vessel endothelial cell migration; • positive regulation of endothelial tube morphogenesis; • lipoxin biosynthetic process;
	Sources:Amigo / QuickGO
Orthologau
	239
	n/a
	ENSG00000108839
	n/a
	P18054
	n/a
	NM_000697
	n/a
	NP_000688
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ALOX12 yw ALOX12 a elwir hefyd yn Arachidonate 12-lipoxygenase, 12S type (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ALOX12.

LOG12
12-LOX
12S-LOX

Llyfryddiaeth

"A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex. ". Psychoneuroendocrinology. 2015. PMID 26372769.
"Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes. ". J Clin Endocrinol Metab. 2015. PMID 25532042.
"Associations between ALOX, COX, and CRP polymorphisms and breast cancer among Hispanic and non-Hispanic white women: The breast cancer health disparities study. ". Mol Carcinog. 2015. PMID 25339205.
"[Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo]. ". Magy Onkol. 2014. PMID 25260086.
"ALOX12 in human toxoplasmosis.". Infect Immun. 2014. PMID 24686056.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ALOX12 - Cronfa NCBI

[2]

[1]