ANXA2

ANXA2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1W7B, 1XJL, 2HYU, 2HYV, 2HYW, 4DRW, 4FTG, 4HRH
Dynodwyr
Cyfenwau	ANXA2, ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV, annexin A2
Dynodwyr allanol	OMIM: 151740 HomoloGene: 20857 GeneCards: ANXA2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phospholipase inhibitor activity; • calcium ion binding; • S100 protein binding; • phospholipase A2 inhibitor activity; • calcium-dependent protein binding; • protease binding; • cytoskeletal protein binding; • GO:0001948, GO:0016582 protein binding; • calcium-dependent phospholipid binding; • phosphatidylinositol-4,5-bisphosphate binding; • cadherin binding involved in cell-cell adhesion; • RNA binding; • identical protein binding; • bone sialoprotein binding; • molecular function regulator; • phosphatidylserine binding; • calcium channel activity; • virion binding; • voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels;
Cydrannau o'r gell	• fesigl; • cytosol; • endosome; • bilen; • late endosome membrane; • melanosome; • ruffle; • Cellbilen; • lipid droplet; • myelin sheath adaxonal region; • Schmidt-Lanterman incisure; • PCSK9-AnxA2 complex; • macropinosome; • basement membrane; • cell surface; • lysosomal membrane; • basolateral plasma membrane; • cell cortex; • midbody; • early endosome; • perinuclear region of cytoplasm; • sarcolemma; • extrinsic component of plasma membrane; • extracellular exosome; • cnewyllyn cell; • extracellular space; • azurophil granule lumen; • cytoplasm; • membrane raft; • GO:0005578 extracellular matrix; • extracellular region; • GO:0009327 protein-containing complex; • collagen-containing extracellular matrix;
Prosesau biolegol	• negative regulation of low-density lipoprotein particle receptor catabolic process; • positive regulation of protein phosphorylation; • protein heterotetramerization; • fibrinolysis; • body fluid secretion; • collagen fibril organization; • positive regulation of fibroblast proliferation; • response to thyroid hormone; • positive regulation of binding; • positive regulation of vesicle fusion; • membrane raft assembly; • angiogenesis; • vesicle budding from membrane; • osteoclast development; • cell-cell adhesion; • GO:0048553 negative regulation of catalytic activity; • positive regulation of receptor recycling; • neutrophil degranulation; • positive regulation of low-density lipoprotein particle clearance; • positive regulation of low-density lipoprotein particle receptor binding; • positive regulation of low-density lipoprotein receptor activity; • positive regulation of receptor-mediated endocytosis involved in cholesterol transport; • negative regulation of formation of structure involved in a symbiotic process; • positive regulation of vacuole organization; • interleukin-12-mediated signaling pathway; • protein localization to plasma membrane; • growth plate cartilage development; • regulation of plasminogen activation; • biomineral tissue development; • positive regulation of chondrocyte differentiation; • positive regulation by host of viral process; • regulation of cytosolic calcium ion concentration; • positive regulation of calcium ion transport; • endocardial cell differentiation; • calcium ion transmembrane transport; • positive regulation of viral life cycle;
	Sources:Amigo / QuickGO
Orthologau
	302
	n/a
	ENSG00000182718
	n/a
	P07355
	n/a
	NM_001002857; NM_001002858; NM_001136015; NM_004039
	n/a
	NP_001002857; NP_001002858; NP_001129487; NP_004030
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ANXA2 yw ANXA2 a elwir hefyd yn Annexin A2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q22.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ANXA2.

P36
ANX2
LIP2
LPC2
CAL1H
LPC2D
ANX2L4
PAP-IV
HEL-S-270

Llyfryddiaeth

"Relationship Between Circulating Tumor Cells and Annexin A2 in Early Breast Cancer Patients. ". Anticancer Res. 2017. PMID 28476852.
"Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis. ". Mol Cancer Res. 2017. PMID 27760843.
"Annexin A2, up-regulated by IL-6, promotes the ossification of ligament fibroblasts from ankylosing spondylitis patients. ". Biomed Pharmacother. 2016. PMID 27697640.
"Integrative Modeling Reveals Annexin A2-mediated Epigenetic Control of Mesenchymal Glioblastoma. ". EBioMedicine. 2016. PMID 27667176.
"Clinical and prognostic role of annexin A2 in adamantinomatous craniopharyngioma.". J Neurooncol. 2017. PMID 27640198.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ANXA2 - Cronfa NCBI

[2]

[1]