AP2A2

Protein sy'n cael ei godio yn y corff dynol gan y genyn AP2A2 yw AP2A2 a elwir hefyd yn AP-2 complex subunit alpha-2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.5.

AP2A2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1B9K, 1KY6, 1KY7, 1KYD, 1KYF, 1KYU, 1QTP, 1QTS, 1W80, 2JKR, 2JKT, 2VJ0, 3HS8
Dynodwyr
Cyfenwau	AP2A2, ADTAB, CLAPA2, HIP-9, HIP9, HYPJ, adaptor related protein complex 2 alpha 2 subunit, adaptor related protein complex 2 subunit alpha 2
Dynodwyr allanol	OMIM: 607242 HomoloGene: 5335 GeneCards: AP2A2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • clathrin adaptor activity • GO:0001948, GO:0016582 protein binding • protein kinase binding • lipid binding • protein domain specific binding • disordered domain specific binding • molecular function Cydrannau o'r gell • endocytic vesicle membrane • cytosol • clathrin-coated endocytic vesicle membrane • bilen • Cellbilen • endolysosome membrane • membrane coat • clathrin-coated pit • AP-2 adaptor complex • clathrin adaptor complex • secretory granule membrane • GO:0016023 cytoplasmic vesicle • ficolin-1-rich granule membrane • clathrin-coated endocytic vesicle Prosesau biolegol • endocytosis • antigen processing and presentation of exogenous peptide antigen via MHC class II • ephrin receptor signaling pathway • GO:0019049, GO:0030683 mitigation of host defenses by virus • clathrin-dependent endocytosis • protein transport • intracellular protein transport • vesicle-mediated transport • microtubule-based movement • Wnt signaling pathway, planar cell polarity pathway • neutrophil degranulation • membrane organization • low-density lipoprotein particle receptor catabolic process • low-density lipoprotein particle clearance • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	161	n/a
Ensembl	ENSG00000281385 ENSG00000280759 ENSG00000183020	n/a
UniProt	O94973	n/a
RefSeq (mRNA)	NM_001242837 NM_012305	n/a
RefSeq (protein)	NP_001229766 NP_036437	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AP2A2.

• HIP9
• HYPJ
• ADTAB
• HIP-9
• CLAPA2

Llyfryddiaeth

• "Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2. ". J Cell Biol. 2017. PMID 28003333.
• "HM1.24 is internalized from lipid rafts by clathrin-mediated endocytosis through interaction with alpha-adaptin. ". J Biol Chem. 2009. PMID 19359243.
• "Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene. ". Gene. 2002. PMID 12036598.
• "The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. ". J Biol Chem. 1996. PMID 8662627.
• "Interaction of Shc with adaptor protein adaptins.". J Biol Chem. 1996. PMID 8617812.