APEX1

APEX1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1BIX, 1CQH, 4LND, 4QH9, 5DFF, 4QHD, 1E9N, 3U8U, 5DFI, 1HD7, 5DG0, 5DFJ, 4QHE, 5DFH, 1DE9, 4IEM, 2ISI, 1DE8, 2O3H, 1CQG, 1DEW, 5CFG
Dynodwyr
Cyfenwau	APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1, apurinic/apyrimidinic endodeoxyribonuclease 1
Dynodwyr allanol	OMIM: 107748 HomoloGene: 1241 GeneCards: APEX1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • nuclease activity; • endonuclease activity; • hydrolase activity; • metal ion binding; • lyase activity; • class I DNA-(apurinic or apyrimidinic site) endonuclease activity; • GO:0032403 protein-containing complex binding; • GO:0001948, GO:0016582 protein binding; • exonuclease activity; • phosphodiesterase I activity; • double-stranded DNA 3'-5' exodeoxyribonuclease activity; • endodeoxyribonuclease activity; • chromatin DNA binding; • endoribonuclease activity; • uracil DNA N-glycosylase activity; • phosphoric diester hydrolase activity; • site-specific endodeoxyribonuclease activity, specific for altered base; • double-stranded telomeric DNA binding; • oxidoreductase activity; • double-stranded DNA exodeoxyribonuclease activity; • GO:0001105 transcription coactivator activity; • NF-kappaB binding; • RNA-DNA hybrid ribonuclease activity; • damaged DNA binding; • GO:0001106 transcription corepressor activity; • 3'-5' exonuclease activity; • DNA-(apurinic or apyrimidinic site) endonuclease activity; • RNA binding; • class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity;
Cydrannau o'r gell	• cytoplasm; • centrosome; • intracellular anatomical structure; • mitocondria; • cnewyllyn cell; • perinuclear region of cytoplasm; • ribosom; • transcription regulator complex; • nuclear speck; • nucleoplasm; • nucleolus; • Reticwlwm endoplasmig;
Prosesau biolegol	• GO:0100026 DNA repair; • nucleic acid phosphodiester bond hydrolysis; • cellular response to DNA damage stimulus; • DNA recombination; • positive regulation of G1/S transition of mitotic cell cycle; • negative regulation of smooth muscle cell migration; • GO:0009373 regulation of transcription, DNA-templated; • DNA demethylation; • cellular response to cAMP; • RNA phosphodiester bond hydrolysis, endonucleolytic; • transcription, DNA-templated; • response to organonitrogen compound; • cellular response to hydrogen peroxide; • cellular response to peptide hormone stimulus; • regulation of mRNA stability; • cellular response to organonitrogen compound; • cell redox homeostasis; • GO:0010260 heneiddio; • base-excision repair; • telomere maintenance; • negative regulation of nucleic acid-templated transcription; • telomere maintenance via base-excision repair; • regulation of apoptotic process; • positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologau
	328
	n/a
	ENSG00000100823
	n/a
	P27695
	n/a
	NM_001244249; NM_001641; NM_080648; NM_080649
	n/a
	NP_001231178; NP_001632; NP_542379; NP_542380
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn APEX1 yw APEX1 a elwir hefyd yn Apurinic/apyrimidinic endodeoxyribonuclease 1 a DNA-(apurinic or apyrimidinic site) lyase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APEX1.

APE
APX
APE1
APEN
APEX
HAP1
REF1

Llyfryddiaeth

"The expression of APE1 in triple-negative breast cancer and its effect on drug sensitivity of olaparib. ". Tumour Biol. 2017. PMID 29064327.
"Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2. ". Nucleic Acids Res. 2017. PMID 28977421.
"Apurinic/apyrimidinic endonuclease 1 (APE1/Ref-1) overexpression is an independent prognostic marker in prostate cancer without TMPRSS2:ERG fusion. ". Mol Carcinog. 2017. PMID 28467610.
"Tumor-associated APE1 variant exhibits reduced complementation efficiency but does not promote cancer cell phenotypes. ". Environ Mol Mutagen. 2017. PMID 28181292.
"Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.". Mol Cell Biol. 2017. PMID 27994014.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] APEX1 - Cronfa NCBI

[2]

[1]