APOA1

APOA1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AV1, 1GW3, 1GW4, 1ODP, 1ODQ, 1ODR, 2A01, 3K2S, 3R2P, 2MSC, 2MSD, 2MSE, 4V6M
Dynodwyr
Cyfenwau	APOA1, entrez:335, apo(a), apolipoprotein A1, Apolipoprotein A-I, HPALP2
Dynodwyr allanol	OMIM: 107680 HomoloGene: 47900 GeneCards: APOA1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• lipase inhibitor activity; • phosphatidylcholine binding; • apolipoprotein receptor binding; • high-density lipoprotein particle receptor binding; • lipoprotein particle binding; • phosphatidylcholine-sterol O-acyltransferase activator activity; • phospholipid binding; • apolipoprotein A-I receptor binding; • enzyme binding; • GO:0017127 cholesterol transfer activity; • amyloid-beta binding; • phospholipid transporter activity; • GO:0001948, GO:0016582 protein binding; • chemorepellent activity; • lipid transporter activity; • cholesterol binding; • identical protein binding; • high-density lipoprotein particle binding; • lipid binding; • heat shock protein binding; • signaling receptor binding;
Cydrannau o'r gell	• cytosol; • endoplasmic reticulum lumen; • chylomicron; • extracellular region; • cnewyllyn cell; • extracellular vesicle; • endocytic vesicle lumen; • discoidal high-density lipoprotein particle; • very-low-density lipoprotein particle; • cell surface; • secretory granule lumen; • extracellular exosome; • blood microparticle; • endocytic vesicle; • Cellbilen; • spherical high-density lipoprotein particle; • early endosome; • high-density lipoprotein particle; • GO:0016023 cytoplasmic vesicle; • extracellular space; • low-density lipoprotein particle; • intermediate-density lipoprotein particle; • collagen-containing extracellular matrix;
Prosesau biolegol	• positive regulation of Rho protein signal transduction; • regulation of protein phosphorylation; • cholesterol import; • lipid transport; • negative chemotaxis; • positive regulation of cholesterol esterification; • phospholipid efflux; • phospholipid transport; • negative regulation of hydrolase activity; • receptor-mediated endocytosis; • retinoid metabolic process; • negative regulation of lipase activity; • regulation of intestinal cholesterol absorption; • negative regulation of cell adhesion molecule production; • peripheral nervous system axon regeneration; • endothelial cell proliferation; • animal organ regeneration; • peptidyl-methionine modification; • cholesterol homeostasis; • negative regulation of heterotypic cell-cell adhesion; • transforming growth factor beta receptor signaling pathway; • negative regulation of inflammatory response; • phospholipid homeostasis; • ERK1 and ERK2 cascade; • GO:0002719 negative regulation of cytokine production involved in immune response; • positive regulation of fatty acid biosynthetic process; • high-density lipoprotein particle clearance; • lipoprotein metabolic process; • G protein-coupled receptor signaling pathway; • positive regulation of triglyceride catabolic process; • response to nutrient; • glucocorticoid metabolic process; • lipid storage; • protein stabilization; • positive regulation of lipoprotein lipase activity; • cholesterol metabolic process; • response to estrogen; • triglyceride catabolic process; • transmembrane transport; • GO:0015915 transport; • cholesterol efflux; • integrin-mediated signaling pathway; • phosphatidylcholine biosynthetic process; • neuron projection regeneration; • negative regulation of very-low-density lipoprotein particle remodeling; • steroid metabolic process; • positive regulation of hydrolase activity; • regulation of Cdc42 protein signal transduction; • blood vessel endothelial cell migration; • negative regulation of tumor necrosis factor-mediated signaling pathway; • lipid metabolism; • cholesterol transport; • platelet degranulation; • adrenal gland development; • high-density lipoprotein particle assembly; • negative regulation of response to cytokine stimulus; • high-density lipoprotein particle remodeling; • positive regulation of substrate adhesion-dependent cell spreading; • phospholipid metabolic process; • GO:0070904 vitamin transport; • cholesterol biosynthetic process; • positive regulation of stress fiber assembly; • triglyceride homeostasis; • reverse cholesterol transport; • lipoprotein biosynthetic process; • positive regulation of cholesterol efflux; • regulation of lipid metabolic process; • regulation of cholesterol transport; • chylomicron remodeling; • very-low-density lipoprotein particle remodeling; • chylomicron assembly; • post-translational protein modification; • positive regulation of lipid biosynthetic process; • positive regulation of phagocytosis; • positive regulation of phospholipid efflux;
	Sources:Amigo / QuickGO
Orthologau
	335
	n/a
	ENSG00000118137
	n/a
	P02647
	n/a
	NM_000039; NM_001318017; NM_001318018; NM_001318021
	n/a
NP_000030; NP_001304946; NP_001304947; NP_001304950; NP_000030.1;
	NP_001304946.1; NP_001304947.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn APOA1 yw APOA1 a elwir hefyd yn Apolipoprotein A-I, isoform CRA_a ac Apolipoprotein A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn APOA1.

apo(a)

Llyfryddiaeth

"Low levels of ApoA1 improve risk prediction of type 2 diabetes mellitus. ". J Clin Lipidol. 2017. PMID 28502492.
"Serum apoprotein A1 levels are inversely associated with disease activity in gout: From a southern Chinese Han population. ". Medicine (Baltimore). 2017. PMID 28445313.
"Inflammatory markers modify the risk of recurrent coronary events associated with apolipoprotein A-I in postinfarction patients. ". J Clin Lipidol. 2017. PMID 28391888.
"Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study. ". Lipids Health Dis. 2017. PMID 28372564.
"In situ AFM imaging of apolipoprotein A-I directly derived from plasma HDL.". Atherosclerosis. 2017. PMID 28279834.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] APOA1 - Cronfa NCBI

[2]

[1]