AQP1

AQP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4CSK, 1FQY, 1H6I, 1IH5
Dynodwyr
Cyfenwau	AQP1, AQP-CHIP, CHIP28, CO, aquaporin 1 (Colton blood group)
Dynodwyr allanol	OMIM: 107776 HomoloGene: 68051 GeneCards: AQP1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transporter activity; • GO:0051739, GO:0015251 ammonium transmembrane transporter activity; • nitric oxide transmembrane transporter activity; • intracellular cGMP-activated cation channel activity; • potassium channel activity; • GO:0022891 transmembrane transporter activity; • carbon dioxide transmembrane transporter activity; • GO:0001948, GO:0016582 protein binding; • water transmembrane transporter activity; • GO:0015388 potassium ion transmembrane transporter activity; • glycerol transmembrane transporter activity; • water channel activity; • ephrin receptor binding; • identical protein binding; • channel activity;
Cydrannau o'r gell	• cytoplasm; • nuclear membrane; • symbiont-containing vacuole membrane; • bilen; • cnewyllyn cell; • apical plasma membrane; • integral component of membrane; • Cellbilen; • apical part of cell; • basal plasma membrane; • integral component of plasma membrane; • brush border membrane; • basolateral plasma membrane; • sarcolemma; • brush border; • symbiont-containing vacuole; • axon; • neuron projection; • axon terminus; • extracellular exosome;
Prosesau biolegol	• cellular response to retinoic acid; • cellular response to mechanical stimulus; • cellular response to copper ion; • cellular response to nitric oxide; • cellular response to hypoxia; • cellular response to cAMP; • carbon dioxide transmembrane transport; • positive regulation of fibroblast proliferation; • cellular homeostasis; • pancreatic juice secretion; • cGMP biosynthetic process; • cellular response to stress; • cellular response to salt stress; • cellular response to inorganic substance; • cell volume homeostasis; • cellular response to UV; • establishment or maintenance of actin cytoskeleton polarity; • negative regulation of apoptotic process; • cellular response to dexamethasone stimulus; • positive regulation of angiogenesis; • odontogenesis; • renal water transport; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cellular response to mercury ion; • nitric oxide transport; • cellular hyperosmotic response; • bicarbonate transport; • positive regulation of saliva secretion; • renal water homeostasis; • multicellular organismal water homeostasis; • transepithelial water transport; • carbon dioxide transport; • cellular response to hydrogen peroxide; • cerebrospinal fluid secretion; • potassium ion transmembrane transport; • ammonium transmembrane transport; • cation transmembrane transport; • glomerular filtration; • potassium ion transport; • water transport; • hyperosmotic response; • response to hormone; • positive regulation of lamellipodium assembly; • positive regulation of epithelial cell migration; • glycerol transport; • sensory perception of pain; • lateral ventricle development; • water homeostasis; • positive regulation of cell migration; • secretion by cell; • secretory granule organization; • wound healing; • hyperosmotic salinity response; • response to estrogen; • lipid digestion; • camera-type eye morphogenesis; • corticotropin secretion; • renal water absorption; • metanephric descending thin limb development; • metanephric proximal straight tubule development; • metanephric proximal convoluted tubule segment 2 development; • metanephric glomerulus vasculature development; • GO:0015915 transport; • cGMP-mediated signaling; • cludo transmembrane rhwng ïonau; • transmembrane transport;
	Sources:Amigo / QuickGO
Orthologau
	358
	n/a
	ENSG00000240583
	n/a
	P29972; Q6JSD8; Q6JSD7
	n/a
NM_198098; NM_000385; NM_001185060; NM_001185061; NM_001185062;
	NM_001329872
	n/a
	NP_001316801; NP_932766
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn AQP1 yw AQP1 a elwir hefyd yn Aquaporin 1 splice variant 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7p14.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AQP1.

CO
CHIP28
AQP-CHIP

Llyfryddiaeth

"Artificial Induction of Native Aquaporin-1 Expression in Human Salivary Cells. ". J Dent Res. 2017. PMID 28072927.
"Overexpression of Aquaporin-1 is a Prognostic Factor for Biochemical Recurrence in Prostate Adenocarcinoma. ". Pathol Oncol Res. 2017. PMID 27817002.
"Red blood cell aquaporin-1 expression is decreased in hereditary spherocytosis. ". Ann Hematol. 2016. PMID 27465156.
"Increased aquaporin 1 expression in the tunica albuginea of Peyronie's disease patients: an in vivo pilot study. ". Histol Histopathol. 2016. PMID 26972451.
"Overexpression of Aquaporin 1 on cysts of patients with polycystic liver disease.". Rev Esp Enferm Dig. 2016. PMID 26838488.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] AQP1 - Cronfa NCBI

[2]

[1]