ARF1

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARF1 yw ARF1 a elwir hefyd yn ADP ribosylation factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q42.13.

ARF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HUR, 1RE0, 1U81, 3O47, 4HMY, 1R8Q, 1RRG, 1RRF
Dynodwyr
Cyfenwau	ARF1, ADP ribosylation factor 1, PVNH8
Dynodwyr allanol	OMIM: 103180 HomoloGene: 133930 GeneCards: ARF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phospholipase D activator activity • nucleotide binding • GTP binding • magnesium ion binding • GO:0006184 GTPase activity • GDP binding • GO:0001948, GO:0016582 protein binding • RNA binding • protein domain specific binding • protein heterodimerization activity Cydrannau o'r gell • extracellular exosome • late endosome • cytoplasm • synapse • trans-Golgi network • Golgi apparatus • cell junction • endomembrane system • peroxisomal membrane • cell leading edge • neuron projection • GO:0097483, GO:0097481 postsynaptic density • postsynaptic membrane • bilen • focal adhesion • intracellular anatomical structure • perinuclear region of cytoplasm • sarcomere • COPI-coated vesicle • cytosol • Golgi membrane • Cellbilen • GO:0009327 protein-containing complex • glutamatergic synapse Prosesau biolegol • positive regulation of endocytosis • positive regulation of protein secretion • very-low-density lipoprotein particle assembly • GO:0019049, GO:0030683 mitigation of host defenses by virus • positive regulation of calcium ion-dependent exocytosis • regulation of receptor internalization • synaptic vesicle budding • small GTPase mediated signal transduction • cellular copper ion homeostasis • long-term depression • antigen processing and presentation of exogenous peptide antigen via MHC class II • Golgi to transport vesicle transport • post-Golgi vesicle-mediated transport • actin filament organization • lysosomal membrane organization • positive regulation of ER to Golgi vesicle-mediated transport • dendritic spine organization • regulation of phospholipid metabolic process • regulation of Arp2/3 complex-mediated actin nucleation • positive regulation of late endosome to lysosome transport • protein transport • phosphatidylinositol biosynthetic process • positive regulation of sodium ion transmembrane transport • vesicle-mediated transport • GO:0048554 positive regulation of catalytic activity • positive regulation of dendritic spine development • mitotic cleavage furrow ingression • interleukin-12-mediated signaling pathway • GO:0015915 transport • intracellular protein transport • Golgi to plasma membrane transport • postsynaptic actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	375	n/a
Ensembl	ENSG00000143761	n/a
UniProt	P84077	n/a
RefSeq (mRNA)	NM_001658 NM_001024226 NM_001024227 NM_001024228	n/a
RefSeq (protein)	NP_001019397 NP_001019398 NP_001019399 NP_001649	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi. ". Mol Biol Cell. 2017. PMID 28428254.
• "ADP-ribosylation factor 1 (ARF1) takes part in cell proliferation and cell adhesion-mediated drug resistance (CAM-DR). ". Ann Hematol. 2017. PMID 28238095.
• "M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin. ". Genes Cells. 2016. PMID 27302278.
• "ADP-ribosylation factor 1 expression regulates epithelial-mesenchymal transition and predicts poor clinical outcome in triple-negative breast cancer. ". Oncotarget. 2016. PMID 26908458.
• "The mechanism and function of mitogen-activated protein kinase activation by ARF1.". Cell Signal. 2015. PMID 26169956.