ARF6

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARF6 yw ARF6 a elwir hefyd yn ADP ribosylation factor 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q21.3.

ARF6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1E0S, 2A5D, 2A5F, 2A5G, 2BAO, 2BAU, 2J5X, 2W83, 3LVQ, 3LVR, 4FME, 3N5C, 3PCR, 4KAX
Dynodwyr
Cyfenwau	ARF6, ADP-ribosylation factor 6, ADP ribosylation factor 6
Dynodwyr allanol	OMIM: 600464 HomoloGene: 1256 GeneCards: ARF6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein N-terminus binding • GTP binding • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • thioesterase binding Cydrannau o'r gell • cytoplasm • recycling endosome • endosome • Golgi apparatus • cell projection • bilen • focal adhesion • ruffle • myelin sheath • Cellbilen • endocytic vesicle • intracellular anatomical structure • cell cortex • early endosome • endosome membrane • extracellular exosome • filopodium membrane • recycling endosome membrane • cleavage furrow • cytosol • Flemming body • early endosome membrane • presynapse • glutamatergic synapse Prosesau biolegol • establishment of epithelial cell polarity • cell differentiation • regulation of filopodium assembly • positive regulation of actin filament polymerization • ruffle organization • small GTPase mediated signal transduction • regulation of Rac protein signal transduction • nervous system development • negative regulation of dendrite development • Cellraniad • negative regulation of receptor-mediated endocytosis • cell adhesion • protein localization to cell surface • protein transport • protein localization to endosome • cell cycle • liver development • myeloid cell apoptotic process • GO:0033109 cortical actin cytoskeleton organization • vesicle-mediated transport • regulation of dendritic spine development • hepatocyte apoptotic process • GO:0015915 transport • positive regulation of protein localization to plasma membrane • intracellular protein transport • regulation of neuron projection development • endocytic recycling • synaptic vesicle endocytosis • positive regulation of keratinocyte migration • ruffle assembly • maintenance of postsynaptic density structure • positive regulation of adherens junction organization • regulation of presynapse assembly • cellular response to nerve growth factor stimulus • negative regulation of protein localization to cell surface • positive regulation of protein secretion • positive regulation of protein homodimerization activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	382	n/a
Ensembl	ENSG00000165527	n/a
UniProt	P62330	n/a
RefSeq (mRNA)	NM_001663	n/a
RefSeq (protein)	NP_001654	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. ". Cancer Lett. 2017. PMID 28025100.
• "RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism. ". Infect Immun. 2016. PMID 27698019.
• "Activation machinery of the small GTPase Arf6. ". Adv Biol Regul. 2014. PMID 24139303.
• "Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. ". Proc Natl Acad Sci U S A. 2013. PMID 24085844.
• "ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies.". PLoS One. 2012. PMID 22666423.