ARF6

ARF6
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1E0S, 2A5D, 2A5F, 2A5G, 2BAO, 2BAU, 2J5X, 2W83, 3LVQ, 3LVR, 4FME, 3N5C, 3PCR, 4KAX
Dynodwyr
Cyfenwau	ARF6, ADP-ribosylation factor 6, ADP ribosylation factor 6
Dynodwyr allanol	OMIM: 600464 HomoloGene: 1256 GeneCards: ARF6
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • protein N-terminus binding; • GTP binding; • GO:0001948, GO:0016582 protein binding; • GO:0006184 GTPase activity; • thioesterase binding;
Cydrannau o'r gell	• cytoplasm; • recycling endosome; • endosome; • Golgi apparatus; • cell projection; • bilen; • focal adhesion; • ruffle; • myelin sheath; • Cellbilen; • endocytic vesicle; • intracellular anatomical structure; • cell cortex; • early endosome; • endosome membrane; • extracellular exosome; • filopodium membrane; • recycling endosome membrane; • cleavage furrow; • cytosol; • Flemming body; • early endosome membrane; • presynapse; • glutamatergic synapse;
Prosesau biolegol	• establishment of epithelial cell polarity; • cell differentiation; • regulation of filopodium assembly; • positive regulation of actin filament polymerization; • ruffle organization; • small GTPase mediated signal transduction; • regulation of Rac protein signal transduction; • nervous system development; • negative regulation of dendrite development; • Cellraniad; • negative regulation of receptor-mediated endocytosis; • cell adhesion; • protein localization to cell surface; • protein transport; • protein localization to endosome; • cell cycle; • liver development; • myeloid cell apoptotic process; • GO:0033109 cortical actin cytoskeleton organization; • vesicle-mediated transport; • regulation of dendritic spine development; • hepatocyte apoptotic process; • GO:0015915 transport; • positive regulation of protein localization to plasma membrane; • intracellular protein transport; • regulation of neuron projection development; • endocytic recycling; • synaptic vesicle endocytosis; • positive regulation of keratinocyte migration; • ruffle assembly; • maintenance of postsynaptic density structure; • positive regulation of adherens junction organization; • regulation of presynapse assembly; • cellular response to nerve growth factor stimulus; • negative regulation of protein localization to cell surface; • positive regulation of protein secretion; • positive regulation of protein homodimerization activity;
	Sources:Amigo / QuickGO
Orthologau
	382
	n/a
	ENSG00000165527
	n/a
	P62330
	n/a
	NM_001663
	n/a
	NP_001654
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARF6 yw ARF6 a elwir hefyd yn ADP ribosylation factor 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q21.3.^[2]

Llyfryddiaeth

"ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer. ". Cancer Lett. 2017. PMID 28025100.
"RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism. ". Infect Immun. 2016. PMID 27698019.
"Activation machinery of the small GTPase Arf6. ". Adv Biol Regul. 2014. PMID 24139303.
"Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. ". Proc Natl Acad Sci U S A. 2013. PMID 24085844.
"ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies.". PLoS One. 2012. PMID 22666423.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ARF6 - Cronfa NCBI

[2]

[1]