ARHGEF11

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGEF11 yw ARHGEF11 a elwir hefyd yn Rho guanine nucleotide exchange factor 11 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q23.1.

ARHGEF11
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HTJ, 1XCG, 2DLS, 3KZ1, 3T06, 5E6P
Dynodwyr
Cyfenwau	ARHGEF11, GTRAP48, PDZ-RHOGEF, Rho guanine nucleotide exchange factor 11
Dynodwyr allanol	OMIM: 605708 HomoloGene: 11409 GeneCards: ARHGEF11
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0001948, GO:0016582 protein binding • guanyl-nucleotide exchange factor activity • G protein-coupled receptor binding Cydrannau o'r gell • cytoplasm • cytosol • bilen Prosesau biolegol • G protein-coupled receptor signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of cell growth • Rho protein signal transduction • establishment of cell polarity • positive regulation of apoptotic process • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • striated muscle contraction • actin cytoskeleton organization • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9826	n/a
Ensembl	ENSG00000132694	n/a
UniProt	O15085	n/a
RefSeq (mRNA)	NM_014784 NM_198236 NM_001377418 NM_001377419	n/a
RefSeq (protein)	NP_055599 NP_937879 NP_001364347 NP_001364348	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGEF11.

• GTRAP48
• PDZ-RHOGEF

Llyfryddiaeth

• "On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF. ". BMC Struct Biol. 2009. PMID 19460155.
• "R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians. ". J Hum Genet. 2008. PMID 18231709.
• "Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population. ". Hum Psychopharmacol. 2014. PMID 25319871.
• "Association of ARHGEF11 R1467H polymorphism with risk for type 2 diabetes mellitus and insulin resistance in Chinese population. ". Mol Biol Rep. 2011. PMID 21210224.
• "The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF.". Biochemistry. 2009. PMID 19618964.