ARHGEF7

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGEF7 yw ARHGEF7 a elwir hefyd yn Rho guanine nucleotide exchange factor (GEF) 7, isoform CRA_b (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 13, band 13q34.

ARHGEF7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BY1, 1ZSG, 2L3G
Dynodwyr
Cyfenwau	ARHGEF7, BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB, Rho guanine nucleotide exchange factor 7
Dynodwyr allanol	OMIM: 605477 HomoloGene: 2895 GeneCards: ARHGEF7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • guanyl-nucleotide exchange factor activity • protein kinase binding Cydrannau o'r gell • cytoplasm • cytosol • cell projection • focal adhesion • ruffle • Cellbilen • cell junction • soma • cell cortex • neuron projection • storage vacuole • lamellipodium • intracellular anatomical structure Prosesau biolegol • regulation of GTP binding • GO:0007243 intracellular signal transduction • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of lamellipodium morphogenesis • Golgi organization • ephrin receptor signaling pathway • nervous system development • focal adhesion assembly • positive regulation of substrate adhesion-dependent cell spreading • positive regulation of growth hormone secretion • hematopoietic progenitor cell differentiation • positive regulation of apoptotic process • positive regulation of protein binding • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of fibroblast migration • GO:0072468 signal transduction • lamellipodium assembly • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8874	n/a
Ensembl	ENSG00000102606	n/a
UniProt	Q14155	n/a
RefSeq (mRNA)	NM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735 NM_001320851 NM_001320852 NM_001320853 NM_001320854 NM_001330597 NM_001330598 NM_001354046 NM_001354047 NM_001354048 NM_001354049 NM_001354050 NM_001354051 NM_001354052 NM_001354053 NM_001354054 NM_001354055 NM_001354056 NM_001354057 NM_001354058 NM_001354059 NM_001354060 NM_001354061	n/a
RefSeq (protein)	NP_001106983 NP_001106984 NP_001106985 NP_001307780 NP_001307781 NP_001307782 NP_001307783 NP_001317526 NP_001317527 NP_003890 NP_663788 NP_001340975 NP_001340976 NP_001340977 NP_001340978 NP_001340979 NP_001340980 NP_001340981 NP_001340982 NP_001340983 NP_001340984 NP_001340985 NP_001340986 NP_001340987 NP_001340988 NP_001340989 NP_001340990 NP_001106985.1 NP_003890.1 NP_001307780.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGEF7.

• P50
• P85
• PAK3
• PIXB
• COOL1
• P50BP
• COOL-1
• P85SPR
• BETA-PIX
• P85COOL1
• Nbla10314

Llyfryddiaeth

• "β-PIX is critical for transplanted mesenchymal stromal cell migration. ". Stem Cells Dev. 2012. PMID 22087847.
• "Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. ". Mol Cell Biol. 2008. PMID 18160719.
• "β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration. ". J Cell Mol Med. 2015. PMID 25683605.
• "The Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of β1PIX with β-catenin. ". J Biol Chem. 2013. PMID 24129564.
• "Hypoxia-induced invadopodia formation: a role for β-PIX.". Open Biol. 2013. PMID 23740575.