ASAP1

Protein sy'n cael ei godio yn y corff dynol gan y genyn ASAP1 yw ASAP1 a elwir hefyd yn ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q24.21-q24.22.

ASAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D1X, 2DA0, 2ED1, 2RQT, 2RQU
Dynodwyr
Cyfenwau	ASAP1, AMAP1, CENTB4, DDEF1, PAG2, PAP, ZG14P, ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Dynodwyr allanol	OMIM: 605953 HomoloGene: 7684 GeneCards: ASAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatidylinositol-4,5-bisphosphate binding • GO:0001948, GO:0016582 protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • metal ion binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • phosphatidylserine binding • cadherin binding Cydrannau o'r gell • cytoplasm • cytosol • dendritic spine • bilen • podosome • cell projection membrane • Cellbilen Prosesau biolegol • cilium assembly • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of dendritic spine development • cell projection organization • positive regulation of podosome assembly • positive regulation of membrane tubulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	50807	n/a
Ensembl	ENSG00000153317	n/a
UniProt	Q9ULH1	n/a
RefSeq (mRNA)	NM_001247996 NM_018482 NM_001362925 NM_001362926 NM_001362924	n/a
RefSeq (protein)	NP_001234925 NP_060952 NP_001349854 NP_001349855 NP_001349853	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ASAP1.

• PAP
• PAG2
• AMAP1
• DDEF1
• ZG14P
• CENTB4

Llyfryddiaeth

• "Overexpression of ASAP1 is associated with poor prognosis in epithelial ovarian cancer. ". Int J Clin Exp Pathol. 2014. PMID 24427349.
• "Autoinhibition of Arf GTPase-activating protein activity by the BAR domain in ASAP1. ". J Biol Chem. 2009. PMID 19017632.
• "No Significant Effect of ASAP1 Gene Variants on the Susceptibility to Tuberculosis in Chinese Population. ". Medicine (Baltimore). 2016. PMID 27227929.
• "Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. ". Nat Genet. 2015. PMID 25774636.
• "ASAP1 mediates the invasive phenotype of human laryngeal squamous cell carcinoma to affect survival prognosis.". Oncol Rep. 2014. PMID 24788532.