ASS1

Protein sy'n cael ei godio yn y corff dynol gan y genyn ASS1 yw ASS1 a elwir hefyd yn Argininosuccinate synthase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.11.

ASS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2NZ2
Dynodwyr
Cyfenwau	ASS1, ASS, CTLN1, Argininosuccinate synthetase 1, argininosuccinate synthase 1
Dynodwyr allanol	OMIM: 603470 HomoloGene: 6899 GeneCards: ASS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • amino acid binding • ligase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • ATP binding • argininosuccinate synthase activity • RNA binding • toxic substance binding Cydrannau o'r gell • extracellular exosome • mitocondria • myelin sheath • cytoplasm • cytosol • cnewyllyn cell • mitochondrial outer membrane • lysosome • Reticwlwm endoplasmig • neuron projection • neuronal cell body • perikaryon • cell body fiber Prosesau biolegol • aspartate metabolic process • cellular response to laminar fluid shear stress • urea cycle • positive regulation of nitric oxide biosynthetic process • negative regulation of leukocyte cell-cell adhesion • cellular amino acid biosynthetic process • citrulline metabolic process • argininosuccinate metabolic process • arginine biosynthetic process • kidney development • liver development • acute-phase response • midgut development • GO:0010260 heneiddio • response to nutrient • Rhythm circadaidd • response to toxic substance • response to zinc ion • response to mycotoxin • response to amine • response to estradiol • response to lipopolysaccharide • response to amino acid • response to peptide hormone • response to steroid hormone • response to glucocorticoid • response to growth hormone • diaphragm development • response to fatty acid • cellular response to lipopolysaccharide • cellular response to amino acid stimulus • cellular response to ammonium ion • cellular response to cAMP • cellular response to interferon-gamma • cellular response to tumor necrosis factor • cellular response to glucagon stimulus • cellular response to oleic acid • cellular response to amine stimulus • cellular response to dexamethasone stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	445	n/a
Ensembl	ENSG00000130707	n/a
UniProt	P00966	n/a
RefSeq (mRNA)	NM_000050 NM_054012	n/a
RefSeq (protein)	NP_000041 NP_446464	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ASS1.

• ASS
• CTLN1

Llyfryddiaeth

• "Argininosuccinate synthase 1 (ASS1): A marker of unclassified hepatocellular adenoma and high bleeding risk. ". Hepatology. 2017. PMID 28646562.
• "Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma. ". PLoS One. 2017. PMID 28187218.
• "Identification of three novel mutations in fourteen patients with citrullinemia type 1. ". Clin Biochem. 2017. PMID 28132756.
• "Mutations in the Human Argininosuccinate Synthetase (ASS1) Gene, Impact on Patients, Common Changes, and Structural Considerations. ". Hum Mutat. 2017. PMID 28111830.
• "Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial.". JAMA Oncol. 2017. PMID 27584578.