ATF2

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATF2 yw ATF2 a elwir hefyd yn Activating transcription factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.

ATF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BHI, 1T2K, 4H36
Dynodwyr
Cyfenwau	ATF2, CRE-BP1, CREB-2, CREB2, HB16, TREB7, activating transcription factor 2
Dynodwyr allanol	OMIM: 123811 HomoloGene: 31061 GeneCards: ATF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • cAMP response element binding protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • chromatin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • nucleic acid binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein kinase binding • cAMP response element binding • histone acetyltransferase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • protein heterodimerization activity Cydrannau o'r gell • cytoplasm • bilen • nucleoplasm • mitochondrial outer membrane • mitocondria • cnewyllyn cell • site of double-strand break Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • mitotic intra-S DNA damage checkpoint signaling • outflow tract morphogenesis • response to water deprivation • positive regulation of DNA-binding transcription factor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • positive regulation of transforming growth factor beta2 production • transcription, DNA-templated • cellular response to DNA damage stimulus • response to osmotic stress • positive regulation of neuron apoptotic process • regulation of DNA-binding transcription factor activity • positive regulation of mitochondrial membrane permeability involved in apoptotic process • negative regulation of epithelial cell proliferation • adipose tissue development • fat cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • amelogenesis • histone acetylation • positive regulation of cardiac muscle myoblast proliferation • GO:1901313 positive regulation of gene expression • negative regulation of angiogenesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1386	n/a
Ensembl	ENSG00000115966	n/a
UniProt	P15336	n/a
RefSeq (mRNA)	NM_001256090 NM_001256091 NM_001256092 NM_001256093 NM_001256094 NM_001880	n/a
RefSeq (protein)	NP_001243019 NP_001243020 NP_001243021 NP_001243022 NP_001243023 NP_001871	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ATF2.

• HB16
• CREB2
• TREB7
• CREB-2
• CRE-BP1

Llyfryddiaeth

• "Splice variants of cytosolic polyadenylation element-binding protein 2 (CPEB2) differentially regulate pathways linked to cancer metastasis. ". J Biol Chem. 2017. PMID 28904175.
• "ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease. ". Pharmacol Res. 2017. PMID 28212892.
• "ATF2 predicts poor prognosis and promotes malignant phenotypes in renal cell carcinoma. ". J Exp Clin Cancer Res. 2016. PMID 27377902.
• "ATF-2 immunoreactivity in post-mitotic and terminally differentiated human odontoblasts. ". Med Mol Morphol. 2015. PMID 25417007.
• "Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.". Breast Cancer Res Treat. 2014. PMID 25141981.