ATP1A1

Protein sy'n cael ei godio yn y corff dynol gan y genyn ATP1A1 yw ATP1A1 a elwir hefyd yn Sodium/potassium-transporting ATPase subunit alpha-1 ac ATPase Na+/K+ transporting subunit alpha 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p13.1.

ATP1A1
Dynodwyr
Cyfenwau	ATP1A1, ATPase, Na+/K+ transporting, alpha 1, ATPase Na+/K+ transporting subunit alpha 1, CMT2DD, HOMGSMR2
Dynodwyr allanol	OMIM: 182310 HomoloGene: 564 GeneCards: ATP1A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • steroid hormone binding • nucleotide binding • chaperone binding • protein domain specific binding • GO:0098519, GO:0098518 phosphatase activity • ADP binding • potassium ion binding • sodium ion binding • P-type sodium:potassium-exchanging transporter activity • metal ion binding • phosphatidylinositol 3-kinase binding • GO:0001948, GO:0016582 protein binding • ankyrin binding • hydrolase activity • ATP binding • protein kinase binding • P-type potassium transmembrane transporter activity Cydrannau o'r gell • integral component of membrane • extracellular vesicle • endosome • Golgi apparatus • bilen • intercalated disc • T-tubule • melanosome • myelin sheath • Cellbilen • sodium:potassium-exchanging ATPase complex • basolateral plasma membrane • apical plasma membrane • Reticwlwm endoplasmig • caveola • membrane raft • sarcolemma • extracellular exosome • GO:0097483, GO:0097481 postsynaptic density • GO:0009327 protein-containing complex Prosesau biolegol • cellular response to steroid hormone stimulus • regulation of cardiac conduction • membrane hyperpolarization • regulation of sodium ion transport • regulation of the force of heart contraction • negative regulation of heart contraction • sodium ion transport • cellular sodium ion homeostasis • sodium ion export across plasma membrane • cell communication by electrical coupling involved in cardiac conduction • response to glycoside • cludo ïon • GO:0097301 cellular potassium ion homeostasis • regulation of blood pressure • potassium ion transport • positive regulation of heart contraction • cludo transmembrane rhwng ïonau • cellular response to mechanical stimulus • regulation of cardiac muscle cell contraction • membrane repolarization • positive regulation of striated muscle contraction • negative regulation of glucocorticoid biosynthetic process • membrane repolarization during cardiac muscle cell action potential • relaxation of cardiac muscle • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • potassium ion import across plasma membrane • establishment or maintenance of transmembrane electrochemical gradient • cardiac muscle cell action potential involved in contraction • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	476	n/a
Ensembl	ENSG00000163399	n/a
UniProt	P05023 Q5TC02	n/a
RefSeq (mRNA)	NM_000701 NM_001001586 NM_001160233 NM_001160234	n/a
RefSeq (protein)	NP_000692 NP_001153705 NP_001153706	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Llyfryddiaeth

• "Correlative study of peripheral ATP1A1 gene expression level to anxiety severity score on major depressive disorder patients. ". J Basic Clin Physiol Pharmacol. 2016. PMID 27487491.
• "Pathogenesis of Adrenal Aldosterone-Producing Adenomas Carrying Mutations of the Na(+)/K(+)-ATPase. ". Endocrinology. 2015. PMID 26418325.
• "Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma. ". Oncotarget. 2015. PMID 26334094.
• "General and specific lipid-protein interactions in Na,K-ATPase. ". Biochim Biophys Acta. 2015. PMID 25791351.
• "ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.". J Virol. 2015. PMID 25653449.