AURKA

Protein sy'n cael ei godio yn y corff dynol gan y genyn AURKA yw AURKA a elwir hefyd yn Aurora kinase A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q13.2.

AURKA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4UZH, 1MQ4, 1MUO, 1OL5, 1OL6, 1OL7, 2BMC, 2C6D, 2C6E, 2DWB, 2J4Z, 2J50, 2NP8, 2W1C, 2W1D, 2W1E, 2W1F, 2W1G, 2WQE, 2WTV, 2WTW, 2X6D, 2X6E, 2X81, 2XNE, 2XNG, 2XRU, 3COH, 3E5A, 3EFW, 3FDN, 3H0Y, 3H0Z, 3H10, 3HA6, 3K5U, 3LAU, 3M11, 3MYG, 3NRM, 3O50, 3O51, 3P9J, 3QBN, 3R21, 3R22, 3UNZ, 3UO4, 3UO5, 3UO6, 3UOD, 3UOH, 3UOJ, 3UOK, 3UOL, 3UP2, 3UP7, 3VAP, 3W10, 3W16, 3W18, 3W2C, 4B0G, 4BN1, 4BYI, 4BYJ, 4C3P, 4C3R, 4CEG, 4DEA, 4DEB, 4DED, 4DEE, 4DHF, 4J8M, 4J8N, 4JAI, 4JAJ, 4JBO, 4JBP, 4JBQ, 4O0S, 4O0U, 4O0W, 4PRJ, 4UYN, 4UZD, 4UTD, 5AAD, 5AAE, 5AAF, 5AAG, 5EW9, 5DR9, 5DPV, 5DN3, 5DRD, 5L8J, 4ZS0, 5DR6
Dynodwyr
Cyfenwau	AURKA, AIK, ARK1, AURA, AURORA2, BTAK, PPP1R47, STK15, STK6, STK7, aurora kinase A
Dynodwyr allanol	OMIM: 603072 HomoloGene: 2670 GeneCards: AURKA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • kinase activity • GO:0001948, GO:0016582 protein binding • protein serine/threonine/tyrosine kinase activity • ATP binding • protein kinase binding • ubiquitin protein ligase binding • protein serine/threonine kinase activity • histone serine kinase activity • protein kinase activity • protein heterodimerization activity Cydrannau o'r gell • cytoplasm • germinal vesicle • cell projection • spindle pole • microtubule cytoskeleton • meiotic spindle • spindle pole centrosome • cilium • microtubule organizing center • chromosome passenger complex • midbody • spindle microtubule • spindle midzone • perinuclear region of cytoplasm • axon hillock • pronucleus • centriole • mitotic spindle • Cytosgerbwd • cnewyllyn cell • microtubule • centrosome • nucleoplasm • spindle • cytosol • mitotic spindle pole Prosesau biolegol • regulation of cytokinesis • regulation of protein stability • phosphorylation • positive regulation of oocyte maturation • centrosome localization • negative regulation of apoptotic process • negative regulation of protein binding • neuron projection extension • Cellraniad • regulation of centrosome cycle • cell projection organization • G2/M transition of mitotic cell cycle • GO:0043147 meiotic spindle organization • mitotic centrosome separation • protein autophosphorylation • anaphase-promoting complex-dependent catabolic process • protein localization to centrosome • cell cycle • anterior/posterior axis specification • positive regulation of mitotic nuclear division • spindle assembly involved in female meiosis I • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • microtubule cytoskeleton organization • regulation of signal transduction by p53 class mediator • GO:0043146 spindle organization • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • GO:0043148 mitotic spindle organization • protein phosphorylation • response to wounding • negative regulation of G2/M transition of mitotic cell cycle • liver regeneration • GO:0007126 Meiosis • GO:0007067 Mitosis • centrosome cycle • regulation of G2/M transition of mitotic cell cycle • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6790	n/a
Ensembl	ENSG00000087586	n/a
UniProt	O14965	n/a
RefSeq (mRNA)	NM_003600 NM_198433 NM_198434 NM_198435 NM_198436 NM_198437 NM_001323303 NM_001323304 NM_001323305	n/a
RefSeq (protein)	NP_001310232 NP_001310233 NP_001310234 NP_003591 NP_940835 NP_940836 NP_940837 NP_940838 NP_940839	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AURKA.

• AIK
• ARK1
• AURA
• BTAK
• STK6
• STK7
• STK15
• PPP1R47

Llyfryddiaeth

• "A single nucleotide polymorphism in codon F31I and V57I of the AURKA gene in invasive ductal breast carcinoma in Middle East. ". Medicine (Baltimore). 2017. PMID 28906374.
• "Switching Aurora-A kinase on and off at an allosteric site. ". FEBS J. 2017. PMID 28342286.
• "AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. ". Biochem Biophys Res Commun. 2017. PMID 28322787.
• "Mechanisms for nonmitotic activation of Aurora-A at cilia. ". Biochem Soc Trans. 2017. PMID 28202658.
• "AURKA Overexpression Is Driven by FOXM1 and MAPK/ERK Activation in Melanoma Cells Harboring BRAF or NRAS Mutations: Impact on Melanoma Prognosis and Therapy.". J Invest Dermatol. 2017. PMID 28188776.