AXIN1

Protein sy'n cael ei godio yn y corff dynol gan y genyn AXIN1 yw AXIN1 a elwir hefyd yn Axin-1 ac Axin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16p13.3.

AXIN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1
Dynodwyr
Cyfenwau	AXIN1, AXIN, PPP1R49, axin 1
Dynodwyr allanol	OMIM: 603816 HomoloGene: 2614 GeneCards: AXIN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-catenin binding • protein homodimerization activity • I-SMAD binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • GO:0001948, GO:0016582 protein binding • enzyme binding • signaling receptor complex adaptor activity • SMAD binding • ubiquitin protein ligase binding • GO:0032947 molecular adaptor activity • protein kinase binding • armadillo repeat domain binding • identical protein binding • signaling adaptor activity Cydrannau o'r gell • cytoplasm • cytosol • lateral plasma membrane • bilen • Cellbilen • perinuclear region of cytoplasm • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • beta-catenin destruction complex • cyrion cell Prosesau biolegol • forebrain anterior/posterior pattern specification • negative regulation of fat cell differentiation • positive regulation of protein phosphorylation • olfactory placode formation • GO:1903364 positive regulation of protein catabolic process • positive regulation of canonical Wnt signaling pathway • embryonic eye morphogenesis • negative regulation of Wnt signaling pathway • positive regulation of JNK cascade • negative regulation of transcription elongation from RNA polymerase II promoter • positive regulation of peptidyl-serine phosphorylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • lens placode formation • determination of left/right symmetry • canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation • positive regulation of ubiquitin-protein transferase activity • positive regulation of peptidyl-threonine phosphorylation • positive regulation of ubiquitin-dependent protein catabolic process • cytoplasmic microtubule organization • canonical Wnt signaling pathway • embryonic skeletal joint morphogenesis • axial mesoderm formation • positive regulation of protein ubiquitination • activation of protein kinase activity • muscle cell development • Wnt-activated signaling pathway involved in forebrain neuron fate commitment • negative regulation of canonical Wnt signaling pathway • GO:0072468 signal transduction • GO:0097285 apoptotic process • beta-catenin destruction complex disassembly • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • Wnt signaling pathway • beta-catenin destruction complex assembly • regulation of Wnt signaling pathway • regulation of intracellular estrogen receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8312	n/a
Ensembl	ENSG00000103126	n/a
UniProt	O15169	n/a
RefSeq (mRNA)	NM_003502 NM_181050	n/a
RefSeq (protein)	NP_003493 NP_851393	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn AXIN1.

• AXIN
• PPP1R49

Llyfryddiaeth

• "AXIN1 and AXIN2 variants in gastrointestinal cancers. ". Cancer Lett. 2014. PMID 25236910.
• "Glycosylation pattern and axin expression in normal and IUGR placentae. ". J Matern Fetal Neonatal Med. 2015. PMID 24846767.
• "The variations in the AXIN1 gene and susceptibility to cryptorchidism. ". J Pediatr Urol. 2015. PMID 25802106.
• "Thr160 of Axin1 is critical for the formation and function of the β-catenin destruction complex. ". Biochem Biophys Res Commun. 2015. PMID 25735981.
• "Association between polymorphisms in AXIN1 gene and atrial septal defect.". Biomarkers. 2014. PMID 25355064.