B4GALT1

Protein sy'n cael ei godio yn y corff dynol gan y genyn B4GALT1 yw B4GALT1 a elwir hefyd yn B4GALT1 protein a Beta-1,4-galactosyltransferase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p21.1.

B4GALT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AE7, 2AEC, 2AES, 2AGD, 2AH9, 2FY7, 2FYA, 2FYB, 3EE5, 4EE3, 4EE4, 4EE5, 4EEA, 4EEG, 4EEM, 4EEO, 4L41
Dynodwyr
Cyfenwau	B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1, beta-1,4-galactosyltransferase 1
Dynodwyr allanol	OMIM: 137060 HomoloGene: 20378 GeneCards: B4GALT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • cytoskeletal protein binding • alpha-tubulin binding • glycosyltransferase activity • lactose synthase activity • transferase activity • beta-tubulin binding • UDP-galactosyltransferase activity • metal ion binding • manganese ion binding • N-acetyllactosamine synthase activity • galactosyltransferase activity • beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Cydrannau o'r gell • Golgi cisterna membrane • Golgi membrane • desmosome • extracellular region • filopodium • brush border membrane • Golgi trans cisterna • integral component of membrane • cell projection • cell surface • external side of plasma membrane • extracellular exosome • basolateral plasma membrane • Cellbilen • Golgi apparatus • bilen • extracellular space • secretory granule membrane • azurophil granule membrane Prosesau biolegol • regulation of acrosome reaction • glycoprotein biosynthetic process • epithelial cell development • penetration of zona pellucida • cell adhesion • lactose biosynthetic process • extracellular matrix organization • positive regulation of apoptotic process involved in mammary gland involution • positive regulation of epithelial cell proliferation involved in wound healing • angiogenesis involved in wound healing • leukocyte migration • wound healing • binding of sperm to zona pellucida • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • acute inflammatory response • branching morphogenesis of an epithelial tube • negative regulation of cell population proliferation • galactose metabolic process • development of secondary sexual characteristics • keratan sulfate biosynthetic process • mammary gland development • regulation of cell population proliferation • positive regulation of apoptotic process • protein N-linked glycosylation • oligosaccharide biosynthetic process • neutrophil degranulation • protein homooligomerization • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2683	n/a
Ensembl	ENSG00000086062	n/a
UniProt	P15291 Q86XA6	n/a
RefSeq (mRNA)	NM_001497	n/a
RefSeq (protein)	NP_001488 NP_001365424 NP_001365425 NP_001365426	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn B4GALT1.

• GT1
• GTB
• CDG2D
• GGTB2
• B4GAL-T1
• beta4Gal-T1

Llyfryddiaeth

• "Increased B4GALT1 expression associates with adverse outcome in patients with non-metastatic clear cell renal cell carcinoma. ". Oncotarget. 2016. PMID 27092876.
• "β-1,4-galactosyltransferase-I activates proliferation and participates in intercellular contacts of lymphocytes. ". Hum Immunol. 2014. PMID 25223470.
• "Estrogen induced β-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells. ". Biochem Biophys Res Commun. 2012. PMID 22982306.
• "Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors. ". Genes Chromosomes Cancer. 2012. PMID 22927297.
• "Binding of N-acetylglucosamine (GlcNAc) β1-6-branched oligosaccharide acceptors to β4-galactosyltransferase I reveals a new ligand binding mode.". J Biol Chem. 2012. PMID 22740701.