BAG3

Protein sy'n cael ei godio yn y corff dynol gan y genyn BAG3 yw BAG3 a elwir hefyd yn BCL2 associated athanogene 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q26.11.

BAG3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UK5
Dynodwyr
Cyfenwau	BAG3, BAG-3, BIS, CAIR-1, MFM6, BCL2 associated athanogene 3, BAG cochaperone 3
Dynodwyr allanol	OMIM: 603883 HomoloGene: 3162 GeneCards: BAG3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • chaperone binding • GO:0001948, GO:0016582 protein binding • adenyl-nucleotide exchange factor activity • cadherin binding • GO:0032403 protein-containing complex binding Cydrannau o'r gell • cytosol • Cellbilen • Z disc • neuron projection • cnewyllyn cell • cytoplasm Prosesau biolegol • negative regulation of striated muscle cell apoptotic process • protein stabilization • negative regulation of apoptotic process • cellular response to mechanical stimulus • brain development • protein folding • spinal cord development • extrinsic apoptotic signaling pathway in absence of ligand • regulation of cellular response to heat • extrinsic apoptotic signaling pathway via death domain receptors • GO:0097285 apoptotic process • GO:0048552 regulation of catalytic activity • cellular response to heat • positive regulation of protein export from nucleus • negative regulation of transcription from RNA polymerase II promoter in response to stress • positive regulation of protein import into nucleus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9531	n/a
Ensembl	ENSG00000151929	n/a
UniProt	O95817	n/a
RefSeq (mRNA)	NM_004281	n/a
RefSeq (protein)	NP_004272	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BAG3.

• BIS
• MFM6
• BAG-3
• CAIR-1

Llyfryddiaeth

• "Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. ". PLoS Pathog. 2017. PMID 28076420.
• "BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins. ". J Mol Biol. 2017. PMID 27884606.
• "Evaluation of BAG3 levels in healthy subjects, hypertensive patients, and hypertensive diabetic patients. ". J Cell Physiol. 2018. PMID 28696030.
• "Expression of Anti-apoptotic Protein BAG3 in Human Sebaceous Gland Carcinoma of the Eyelid. ". Anticancer Res. 2017. PMID 28373462.
• "Whole exome sequencing identified 1 base pair novel deletion in BCL2-associated athanogene 3 (BAG3) gene associated with severe dilated cardiomyopathy (DCM) requiring heart transplant in multiple family members.". Am J Med Genet A. 2017. PMID 28211974.