BCL2L1

Protein sy'n cael ei godio yn y corff dynol gan y genyn BCL2L1 yw BCL2L1 a elwir hefyd yn BCL2 like 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20q11.21.

BCL2L1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 5AGW, 5AGX, 4Z9V, 5FMK, 5FMJ, 5C3G
Dynodwyr
Cyfenwau	BCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BCLXS, PPP1R52, bcl-xS, BCL2L, BCLX, Bcl-X, bcl-xL, BCL2 like 1
Dynodwyr allanol	OMIM: 600039 HomoloGene: 7639 GeneCards: BCL2L1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • BH3 domain binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein kinase binding • protein homodimerization activity • protein heterodimerization activity Cydrannau o'r gell • cytoplasm • integral component of membrane • cytosol • centrosome • nuclear membrane • mitochondrial membranes • bilen • Bcl-2 family protein complex • synapse • intracellular anatomical structure • synaptic vesicle membrane • microtubule organizing center • cell junction • mitochondrial matrix • mitocondria • mitochondrial inner membrane • Cytosgerbwd • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • Reticwlwm endoplasmig • mitochondrial outer membrane Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • neuron apoptotic process • germ cell development • negative regulation of execution phase of apoptosis • regulation of apoptotic process • response to cytokine • male gonad development • endocytosis • negative regulation of intrinsic apoptotic signaling pathway • mitotic cell cycle checkpoint signaling • negative regulation of release of cytochrome c from mitochondria • response to virus • negative regulation of apoptotic process • response to cycloheximide • in utero embryonic development • cellular response to alkaloid • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • regulation of mitochondrial membrane potential • regulation of mitochondrial membrane permeability • apoptotic mitochondrial changes • cellular response to gamma radiation • spermatogenesis • positive regulation of cell population proliferation • positive regulation of apoptotic process • cellular response to amino acid stimulus • ovarian follicle development • apoptotic process in bone marrow cell • fertilization • response to radiation • suppression by virus of host apoptotic process • cell population proliferation • mitochondrion morphogenesis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of autophagy • positive regulation of intrinsic apoptotic signaling pathway • negative regulation of anoikis • hepatocyte apoptotic process • release of cytochrome c from mitochondria • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • GO:0097285 apoptotic process • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • growth • negative regulation of protein localization to plasma membrane • cytokine-mediated signaling pathway • regulation of cytokinesis • regulation of growth • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	598	n/a
Ensembl	ENSG00000171552	n/a
UniProt	Q07817 Q5TE64	n/a
RefSeq (mRNA)	NM_001191 NM_138578 NM_001317919 NM_001317920 NM_001317921 NM_001322239 NM_001322240 NM_001322242	n/a
RefSeq (protein)	NP_001182 NP_001304848 NP_001304849 NP_001304850 NP_001309168 NP_001309169 NP_001309171 NP_612815	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BCL2L1.

• BCLX
• BCL2L
• Bcl-X
• PPP1R52
• BCL-XL/S

Llyfryddiaeth

• "Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts. ". PLoS One. 2016. PMID 27398719.
• "Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL. ". Protein Expr Purif. 2016. PMID 26923059.
• "Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG. ". PLoS One. 2017. PMID 28085926.
• "Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging. ". Aging (Albany NY). 2016. PMID 27794564.
• "Modulation of Bcl-x Alternative Splicing Induces Apoptosis of Human Hepatic Stellate Cells.". Biomed Res Int. 2016. PMID 27579319.