BIRC3

Protein sy'n cael ei godio yn y corff dynol gan y genyn BIRC3 yw BIRC3 a elwir hefyd yn Baculoviral IAP repeat containing 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q22.2.

BIRC3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2UVL, 3EB5, 3EB6, 3M0A, 3M0D
Dynodwyr
Cyfenwau	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2, baculoviral IAP repeat containing 3, IAP-1
Dynodwyr allanol	OMIM: 601721 HomoloGene: 899 GeneCards: BIRC3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • GO:0001948, GO:0016582 protein binding • GO:0050372 ubiquitin-protein transferase activity • transferase activity • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity Cydrannau o'r gell • cytoplasm • nucleoplasm • membrane raft • cnewyllyn cell • cytosol • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • regulation of nucleotide-binding oligomerization domain containing signaling pathway • regulation of innate immune response • regulation of toll-like receptor signaling pathway • negative regulation of necroptotic process • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • regulation of cysteine-type endopeptidase activity • regulation of RIG-I signaling pathway • regulation of tumor necrosis factor-mediated signaling pathway • negative regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • mitotic spindle assembly • cell surface receptor signaling pathway • NIK/NF-kappaB signaling • spermatogenesis • regulation of inflammatory response • positive regulation of I-kappaB kinase/NF-kappaB signaling • I-kappaB kinase/NF-kappaB signaling • positive regulation of protein ubiquitination • GO:0097285 apoptotic process • protein ubiquitination • protein deubiquitination • regulation of necroptotic process • protein heterooligomerization • MyD88-independent toll-like receptor signaling pathway • TRIF-dependent toll-like receptor signaling pathway • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	330	n/a
Ensembl	ENSG00000023445	n/a
UniProt	Q13489	n/a
RefSeq (mRNA)	NM_001165 NM_182962	n/a
RefSeq (protein)	NP_001156 NP_892007	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BIRC3.

• AIP1
• API2
• MIHC
• CIAP2
• HAIP1
• HIAP1
• MALT2
• RNF49
• c-IAP2

Llyfryddiaeth

• "cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-κB pathway. ". Cancer Sci. 2017. PMID 28295868.
• "BIRC3 single nucleotide polymorphism associate with asthma susceptibility and the abundance of eosinophils and neutrophils. ". J Asthma. 2017. PMID 27304223.
• "Helicobacter pyloriEradication Downregulates Cellular Inhibitor of Apoptosis Protein 2 in Gastric Carcinogenesis. ". Gut Liver. 2017. PMID 27282269.
• "BIRC3 is a novel driver of therapeutic resistance in Glioblastoma. ". Sci Rep. 2016. PMID 26888114.
• "Regulation of antiapoptotic and cytoprotective pathways in colonic epithelial cells in ulcerative colitis.". Scand J Gastroenterol. 2015. PMID 26513451.