BRD4

Protein sy'n cael ei godio yn y corff dynol gan y genyn BRD4 yw BRD4 a elwir hefyd yn Bromodomain containing 4, isoform CRA_c a Bromodomain containing 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.12.

BRD4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2I8N, 2LSP, 2MJV, 2OSS, 2OUO, 2YEL, 2YEM, 3MXF, 3P5O, 3SVF, 3SVG, 3U5J, 3U5K, 3U5L, 3UVW, 3UVX, 3UVY, 3UW9, 3ZYU, 4A9L, 4BJX, 4BW1, 4BW2, 4BW3, 4BW4, 4C66, 4C67, 4CFK, 4CFL, 4CL9, 4CLB, 4DON, 4E96, 4F3I, 4GPJ, 4HBV, 4HBW, 4HBX, 4HBY, 4HXK, 4HXL, 4HXM, 4HXN, 4HXO, 4HXP, 4HXR, 4HXS, 4IOO, 4IOQ, 4IOR, 4J0R, 4J0S, 4J3I, 4KV1, 4KV4, 4LR6, 4LRG, 4LYI, 4LYS, 4LYW, 4LZR, 4LZS, 4MEN, 4MEO, 4MEP, 4MEQ, 4MR3, 4MR4, 4NQM, 4NR8, 4NUC, 4NUD, 4NUE, 4O70, 4O71, 4O72, 4O74, 4O75, 4O76, 4O77, 4O78, 4O7A, 4O7B, 4O7C, 4O7E, 4O7F, 4OGI, 4OGJ, 4PCE, 4PCI, 4PS5, 4QB3, 4QR3, 4QR4, 4QR5, 4QZS, 4UIX, 4UIZ, 4UYD, 4WIV, 4XY9, 4XYA, 4Z1Q, 4Z1S, 4Z93, 5A5S, 5A85, 5BT4, 5D3T, 5D3S, 5D3H, 5D3J, 5CTL, 4WHW, 5D3R, 4X2I, 5CPE, 5CRZ, 4YH3, 4ZC9, 5EI4, 5D3P, 5CQT, 5D3L, 5EIS, 5CRM, 5D0C, 5EGU, 5CP5, 5D25, 5CY9, 5COI, 5D26, 4YH4, 5CS8, 5ACY, 5DX4, 5D24, 5HM0, 5HLS, 2N3K, 5JWM, 5DLX, 2NCZ, 2NNU, 5DW2, 2ND1, 4ZW1, 5CFW, 2ND0, 5DLZ
Dynodwyr
Cyfenwau	BRD4, CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4
Dynodwyr allanol	OMIM: 608749 HomoloGene: 137685 GeneCards: BRD4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • p53 binding • chromatin binding • GO:0001948, GO:0016582 protein binding • lysine-acetylated histone binding • RNA polymerase II complex binding • RNA polymerase II CTD heptapeptide repeat kinase activity • enzyme binding • RNA polymerase II C-terminal domain binding • P-TEFb complex binding Cydrannau o'r gell • nucleoplasm • Cromosom • condensed nuclear chromosome • cnewyllyn cell • cytosol Prosesau biolegol • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • negative regulation of DNA damage checkpoint • regulation of transcription involved in G1/S transition of mitotic cell cycle • transcription, DNA-templated • cellular response to DNA damage stimulus • regulation of inflammatory response • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of G2/M transition of mitotic cell cycle • regulation of phosphorylation of RNA polymerase II C-terminal domain • GO:0022415 viral process • positive regulation of transcription elongation from RNA polymerase II promoter • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • protein phosphorylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of histone H3-K36 trimethylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23476	n/a
Ensembl	ENSG00000141867	n/a
UniProt	O60885	n/a
RefSeq (mRNA)	NM_014299 NM_058243 NM_001330384 NM_001379291 NM_001379292	n/a
RefSeq (protein)	NP_001317313 NP_055114 NP_490597 NP_001366220 NP_001366221	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BRD4.

• CAP
• MCAP
• HUNK1
• HUNKI

Llyfryddiaeth

• "Inhibition of BRD4 Suppresses Cell Proliferation and Induces Apoptosis in Renal Cell Carcinoma. ". Cell Physiol Biochem. 2017. PMID 28391274.
• "Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer. ". BMC Genomics. 2017. PMID 28359301.
• "The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes. ". Mol Cell. 2017. PMID 28844864.
• "Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4. ". Mol Cell Biol. 2017. PMID 28694331.
• "Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.". Mol Cell. 2017. PMID 28525743.