BTK

BTK
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1AWW, 1AWX, 1B55, 1BTK, 1BWN, 1K2P, 1QLY, 2GE9, 2Z0P, 3GEN, 3K54, 3OCS, 3OCT, 3P08, 3PIX, 3PIY, 3PIZ, 3PJ1, 3PJ2, 3PJ3, 4NWM, 4OT5, 4OT6, 4OTF, 4OTQ, 4OTR, 4RFY, 4RFZ, 4RG0, 4YHF, 4Z3V, 4ZLY, 4ZLZ, 5BPY, 5BQ0, 5FBN, 4RX5, 5FBO
Dynodwyr
Cyfenwau	BTK, AGMX1, AT, ATK, BPK, IMD1, PSCTK1, XLA, Bruton tyrosine kinase, IGHD3
Dynodwyr allanol	OMIM: 300300 HomoloGene: 30953 GeneCards: BTK
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• metal ion binding; • nucleotide binding; • lipid binding; • signaling receptor binding; • identical protein binding; • protein kinase activity; • transferase activity; • kinase activity; • phosphatidylinositol-3,4,5-trisphosphate binding; • non-membrane spanning protein tyrosine kinase activity; • ATP binding; • GO:0001948, GO:0016582 protein binding; • protein tyrosine kinase activity;
Cydrannau o'r gell	• cytoplasm; • cnewyllyn cell; • bilen; • membrane raft; • extrinsic component of cytoplasmic side of plasma membrane; • GO:0016023 cytoplasmic vesicle; • cytosol; • Cellbilen; • perinuclear region of cytoplasm; • mast cell granule;
Prosesau biolegol	• transmembrane receptor protein tyrosine kinase signaling pathway; • mesoderm development; • GO:0007243 intracellular signal transduction; • peptidyl-tyrosine autophosphorylation; • B cell activation; • positive regulation of NF-kappaB transcription factor activity; • transcription, DNA-templated; • positive regulation of B cell differentiation; • B cell receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • regulation of cell population proliferation; • adaptive immune response; • GO:0097285 apoptotic process; • peptidyl-tyrosine phosphorylation; • protein phosphorylation; • GO:0032697 negative regulation of cytokine production; • MyD88-dependent toll-like receptor signaling pathway; • apoptotic signaling pathway; • calcium-mediated signaling; • I-kappaB kinase/NF-kappaB signaling; • innate immune response; • GO:0009373 regulation of transcription, DNA-templated; • cell maturation; • immune system process; • regulation of B cell cytokine production; • regulation of B cell apoptotic process; • phosphorylation; • histamine secretion by mast cell; • response to organic substance; • positive regulation of type III hypersensitivity; • protein autophosphorylation; • GO:0072353 cellular response to reactive oxygen species; • cellular response to molecule of fungal origin; • positive regulation of type I hypersensitivity; • B cell affinity maturation; • negative regulation of B cell proliferation; • cellular response to interleukin-7; • T cell receptor signaling pathway; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	695
	n/a
	ENSG00000010671
	n/a
	Q06187
	n/a
	NM_001287345; NM_000061; NM_001287344
	n/a
	NP_000052; NP_001274273; NP_001274274
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BTK yw BTK a elwir hefyd yn Bruton tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq22.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BTK.

AT
ATK
BPK
XLA
IMD1
AGMX1
PSCTK1

Llyfryddiaeth

"Establishing a chemical genetic link between Bruton tyrosine kinase activity in malignant B cells and cell functions involved in the micro-environmental dialogue. ". Br J Haematol. 2017. PMID 28573668.
"The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement. ". PLoS One. 2017. PMID 28422989.
"Pseudomonas aeruginosa Liver Abscess as the First Manifestation of X-Linked Agammaglobulinemia With a Novel Mutation. ". J Investig Allergol Clin Immunol. 2017. PMID 28398200.
"Bone marrow mesenchymal stem cells regulate stemness of multiple myeloma cell lines via BTK signaling pathway. ". Leuk Res. 2017. PMID 28273548.
"BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses.". Cancer Res. 2016. PMID 27630139.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] BTK - Cronfa NCBI

[2]

[1]