CCNB1

CCNB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2B9R, 2JGZ, 4Y72, 5HQ0, 4YC3
Dynodwyr
Cyfenwau	CCNB1, CCNB, cyclin B1
Dynodwyr allanol	OMIM: 123836 HomoloGene: 68982 GeneCards: CCNB1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• histone kinase activity; • kinase activity; • patched binding; • GO:0001948, GO:0016582 protein binding; • cyclin-dependent protein serine/threonine kinase activity; • GO:0016534 cyclin-dependent protein serine/threonine kinase activator activity; • ubiquitin-like protein ligase binding; • protein kinase binding; • protein kinase activity; • cyclin-dependent protein serine/threonine kinase regulator activity;
Cydrannau o'r gell	• cytoplasm; • centrosome; • spindle pole; • bilen; • nucleoplasm; • microtubule organizing center; • Cytosgerbwd; • cnewyllyn cell; • cytosol; • mitochondrial matrix; • cyclin B1-CDK1 complex; • cyclin-dependent protein kinase holoenzyme complex;
Prosesau biolegol	• GO:0033128 negative regulation of protein phosphorylation; • response to DDT; • regulation of mitotic cell cycle spindle assembly checkpoint; • positive regulation of mRNA 3'-end processing; • tissue regeneration; • positive regulation of fibroblast proliferation; • cellular response to iron(III) ion; • GO:1904579 cellular response to organic cyclic compound; • response to mechanical stimulus; • positive regulation of mitotic cell cycle; • in utero embryonic development; • negative regulation of gene expression; • regulation of cell cycle; • Cellraniad; • positive regulation of attachment of spindle microtubules to kinetochore; • protein phosphorylation; • mitotic nuclear membrane disassembly; • cellular response to fatty acid; • positive regulation of cardiac muscle cell proliferation; • positive regulation of cell cycle; • G2/M transition of mitotic cell cycle; • oocyte maturation; • spermatogenesis; • cell cycle; • mitotic metaphase plate congression; • anaphase-promoting complex-dependent catabolic process; • regulation of chromosome condensation; • digestive tract development; • ventricular cardiac muscle cell development; • cellular response to hypoxia; • response to toxic substance; • GO:0043148 mitotic spindle organization; • GO:0007067 Mitosis; • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; • positive regulation of mitochondrial ATP synthesis coupled electron transport; • positive regulation of G2/M transition of mitotic cell cycle; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • GO:0034622 protein-containing complex assembly; • regulation of cyclin-dependent protein serine/threonine kinase activity; • regulation of mitotic nuclear division; • positive regulation of cell population proliferation; • transcription initiation from RNA polymerase II promoter; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	891
	n/a
	ENSG00000134057
	n/a
	P14635
	n/a
	NM_031966; NM_001354844; NM_001354845
	n/a
	NP_114172; NP_001341773; NP_001341774
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCNB1 yw CCNB1 a elwir hefyd yn G2/mitotic-specific cyclin-B1 a Cyclin B1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q13.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCNB1.

CCNB

Llyfryddiaeth

"Activity of cyclin B1 in HL-60 cells treated with etoposide. ". Acta Histochem. 2016. PMID 27297620.
"Sodium butyrate down-regulates tristetraprolin-mediated cyclin B1 expression independent of the formation of processing bodies. ". Int J Biochem Cell Biol. 2015. PMID 26555753.
"The Tumor Antigen Cyclin B1 Hosts Multiple CD4 T Cell Epitopes Differently Recognized by Pre-Existing Naive and Memory Cells in Both Healthy and Cancer Donors. ". J Immunol. 2015. PMID 26136431.
"Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function. ". Int J Biol Markers. 2015. PMID 25982682.
"Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.". Cell Cycle. 2014. PMID 25486360.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] CCNB1 - Cronfa NCBI

[2]

[1]