CCNE1

Protein sy'n cael ei godio yn y corff dynol gan y genyn CCNE1 yw CCNE1 a elwir hefyd yn Cyclin E variant ex5del a G1/S-specific cyclin-E1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q12.

CCNE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1W98
Dynodwyr
Cyfenwau	CCNE1, CCNE, pcyclin E1
Dynodwyr allanol	OMIM: 123837 HomoloGene: 14452 GeneCards: CCNE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001105 transcription coactivator activity • kinase activity • cyclin-dependent protein serine/threonine kinase regulator activity • GO:0001948, GO:0016582 protein binding • androgen receptor binding • protein kinase binding • cyclin-dependent protein serine/threonine kinase activity • protein kinase activity Cydrannau o'r gell • cytosol • cyclin-dependent protein kinase holoenzyme complex • nucleoplasm • cnewyllyn cell • cyclin E1-CDK2 complex • cytoplasm • centrosome Prosesau biolegol • androgen receptor signaling pathway • Wnt signaling pathway • regulation of transcription involved in G1/S transition of mitotic cell cycle • regulation of cell cycle • Cellraniad • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein phosphorylation • DNA replication initiation • cell cycle • regulation of protein kinase activity • GO:1901227 negative regulation of transcription by RNA polymerase II • telomere maintenance • homologous chromosome pairing at meiosis • GO:0051178 chromosome organization involved in meiotic cell cycle • G1/S transition of mitotic cell cycle • regulation of cyclin-dependent protein serine/threonine kinase activity • GO:0007067 Mitosis • regulation of mitotic nuclear division • positive regulation of cell population proliferation • positive regulation of cell cycle • positive regulation of G1/S transition of mitotic cell cycle • GO:0007090 mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	898	n/a
Ensembl	ENSG00000105173	n/a
UniProt	P24864	n/a
RefSeq (mRNA)	NM_001238 NM_057182 NM_001322259 NM_001322261 NM_001322262	n/a
RefSeq (protein)	NP_001229 NP_001309188 NP_001309190 NP_001309191 NP_001309188.1 NP_001309190.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CCNE1.

• CCNE
• pCCNE1

Llyfryddiaeth

• "Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer. ". Oncotarget. 2017. PMID 28107181.
• "CCNE1 amplification is associated with aggressive potential in endometrioid endometrial carcinomas. ". Int J Oncol. 2016. PMID 26647729.
• "Oncolytic adenovirus targeting cyclin E overexpression repressed tumor growth in syngeneic immunocompetent mice. ". BMC Cancer. 2015. PMID 26475304.
• "Cyclin E Expression Correlates with Cancer-specific Survival in Endometrial Endometrioid Adenocarcinoma. ". Anticancer Res. 2015. PMID 26026100.
• "Transcriptome Signature and Regulation in Human Somatic Cell Reprogramming.". Stem Cell Reports. 2015. PMID 26004630.