CD40

Protein sy'n cael ei godio yn y corff dynol gan y genyn CD40 yw CD40 a elwir hefyd yn CD40 molecule (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.

CD40
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CZZ, 1D00, 1FLL, 1LB6, 3QD6, 5DMJ, 5IHL, 5DMI
Dynodwyr
Cyfenwau	CD40, Bp50, CDW40, TNFRSF5, p50, CD40 (protein), CD40 molecule
Dynodwyr allanol	OMIM: 109535 HomoloGene: 954 GeneCards: CD40
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0003823, GO:0051635 antigen binding • signal transducer activity • GO:0001948, GO:0016582 protein binding • tumor necrosis factor-activated receptor activity • enzyme binding • ubiquitin protein ligase binding • protein domain specific binding • signaling receptor activity Cydrannau o'r gell • cytoplasm • integral component of membrane • intracellular membrane-bounded organelle • bilen • Cellbilen • integral component of plasma membrane • extracellular region • cell surface • CD40 receptor complex • extracellular exosome • external side of plasma membrane • extracellular space • neuronal cell body • varicosity Prosesau biolegol • positive regulation of protein phosphorylation • positive regulation of MAP kinase activity • positive regulation of interleukin-12 production • protein kinase B signaling • positive regulation of protein kinase C signaling • immune system process • cellular calcium ion homeostasis • tumor necrosis factor-mediated signaling pathway • immune response-regulating cell surface receptor signaling pathway • platelet activation • multicellular organism development • B cell activation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • response to lipopolysaccharide • B cell proliferation • cellular response to mechanical stimulus • positive regulation of endothelial cell apoptotic process • regulation of cell population proliferation • positive regulation of B cell proliferation • positive regulation of NF-kappaB transcription factor activity • defense response to virus • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • positive regulation of isotype switching to IgG isotypes • cellular response to lipopolysaccharide • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • defense response to protozoan • response to bacterium • response to nutrient levels • response to cobalamin • response to interferon-gamma • cellular response to erythropoietin • cellular response to interleukin-1 • cellular response to tumor necrosis factor • response to peptide • inflammatory response • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of blood vessel endothelial cell migration • positive regulation of angiogenesis • GO:0034622 protein-containing complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	958	n/a
Ensembl	ENSG00000101017	n/a
UniProt	P25942	n/a
RefSeq (mRNA)	NM_001250 NM_001302753 NM_152854 NM_001322421 NM_001322422 NM_001362758	n/a
RefSeq (protein)	NP_001241 NP_001289682 NP_001309350 NP_001309351 NP_690593 NP_001349687	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD40.

• p50
• Bp50
• CDW40
• TNFRSF5

Llyfryddiaeth

• "Single nucleotide polymorphisms in the CD40 gene associate with the disease susceptibility and severity in knee osteoarthritis in the Chinese Han population: a case-control study. ". BMC Musculoskelet Disord. 2017. PMID 28320398.
• "A High Level of Soluble CD40L Is Associated with P. aeruginosa Infection in Patients with Cystic Fibrosis. ". PLoS One. 2016. PMID 28030642.
• "Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation. ". Circ Res. 2016. PMID 27992360.
• "Investigation of CD40 gene rs4810485 and rs1883832 mutations in patients with recurrent aphthous stomatitis. ". Arch Oral Biol. 2017. PMID 27875792.
• "CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico.". Genet Mol Res. 2016. PMID 27813548.